Homozygous Protein C Deficiency in a Newborn: Clinicopathologic Correlation

Seth Tarras, Carlos Gadia, Lynn Meister, Eneida Roldan, Jocelyn B. Gregorios

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A rare case of homozygous protein C deficiency occurred in a newborn. The patient presented with purpura fulminans in the first few hours after birth and showed multiple hemorrhagic lesions on computed tomography of the brain at 5 days of age. Nerologic symptoms developed at two weeks and the patient died at 37 weeks. His protein C level was less than 5%. Autopsy revealed thrombosis of the dural sinuses, multiple cortical infarcts, intraparenchymal hemorrhages, and hydrocephalus. The pathologic findings are correlated with the neurologic deficits and previously documented cases are reviewed.

Original languageEnglish (US)
Pages (from-to)214-216
Number of pages3
JournalArchives of neurology
Volume45
Issue number2
DOIs
StatePublished - Feb 1988

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology

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