Homozygous protein C deficiency in a newborn. Clinicopathologic correlation

S. Tarras, C. Gadia, L. Meister, E. Roldan, J. B. Gregorios

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A rare case of homozygous protein C deficiency occurred in a newborn. The patient presented with purpura fulminans in the first few hours after birth and showed multiple hemorrhagic lesions on computed tomography of the brain at 5 days of age. Nerologic symptoms developed at two weeks and the patient died at 37 weeks. His protein C level was less than 5%. Autopsy revealed thrombosis of the dural sinuses, multiple cortical infarcts, intraparenchymal hemorrhages, and hydrocephalus. The pathologic findings are correlated with the neurologic deficits and previously documented cases are reviewed.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalArchives of Neurology
Volume45
Issue number2
StatePublished - Jan 1 1988

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Protein C Deficiency
Purpura Fulminans
Newborn Infant
Multiple Birth Offspring
Intracranial Sinus Thrombosis
Hydrocephalus
Neurologic Manifestations
Protein C
Autopsy
Tomography
Hemorrhage
Brain
Protein
Newborn
Lesion
Computed Tomography

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tarras, S., Gadia, C., Meister, L., Roldan, E., & Gregorios, J. B. (1988). Homozygous protein C deficiency in a newborn. Clinicopathologic correlation. Archives of Neurology, 45(2), 214-216.

Homozygous protein C deficiency in a newborn. Clinicopathologic correlation. / Tarras, S.; Gadia, C.; Meister, L.; Roldan, E.; Gregorios, J. B.

In: Archives of Neurology, Vol. 45, No. 2, 01.01.1988, p. 214-216.

Research output: Contribution to journalArticle

Tarras, S, Gadia, C, Meister, L, Roldan, E & Gregorios, JB 1988, 'Homozygous protein C deficiency in a newborn. Clinicopathologic correlation', Archives of Neurology, vol. 45, no. 2, pp. 214-216.
Tarras S, Gadia C, Meister L, Roldan E, Gregorios JB. Homozygous protein C deficiency in a newborn. Clinicopathologic correlation. Archives of Neurology. 1988 Jan 1;45(2):214-216.
Tarras, S. ; Gadia, C. ; Meister, L. ; Roldan, E. ; Gregorios, J. B. / Homozygous protein C deficiency in a newborn. Clinicopathologic correlation. In: Archives of Neurology. 1988 ; Vol. 45, No. 2. pp. 214-216.
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