HLA‐A *8001 is a member of a newly discovered ancient family of HLA‐A alleles

Annette G. Wagner, Austin L. Hughes, Mary L. Iandoll, Dod Stawart, Susie Herbert, David I. Watkins, Carolyn Katovich Hurley, Sandra Rosen‐Bronson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A member of a new HLA-A locus family, HLA-A(*)8001, has been characterized from 3 African-American individuals expressing a unique HLA-A serologic specificity. The HLA-A(*)8001 sequence is most closely related to alleles of the HLA-A1/3/11 family, although it also contains residues characteristic of the HLA-A2/28, -A9, -A10, and -A19 families. More importantly, the HLA-A(*)8001 sequence contains four unique nonsynonymous (amino acid replacing) nucleotide substitutions absent from all other primate A locus alleles. In addition, five other nucleotide substitutions, four nonsynonymous and one synonymous (silent), observed only in non-human primate A locus alleles were found. Neighbor-joining tree analysis of HLA-A(*)8001 supports the notion that the HLA-A(*)8001 allele is a member of a new HLA-A locus family which was derived from the ancestral A3 lineage but diverged early in the evolution of the HLA-A locus.

Original languageEnglish (US)
Pages (from-to)522-529
Number of pages8
JournalTissue Antigens
Volume42
Issue number5
DOIs
StatePublished - Nov 1993
Externally publishedYes

Keywords

  • Evolution
  • HLA class I
  • HLA-A family
  • Nucleotide sequence

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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    Wagner, A. G., Hughes, A. L., Iandoll, M. L., Stawart, D., Herbert, S., Watkins, D. I., Hurley, C. K., & Rosen‐Bronson, S. (1993). HLA‐A *8001 is a member of a newly discovered ancient family of HLA‐A alleles. Tissue Antigens, 42(5), 522-529. https://doi.org/10.1111/j.1399-0039.1993.tb02198.x