TY - JOUR
T1 - HLA class I/NK cell receptor interaction in early human decidua basalis
T2 - Possible functional consequences
AU - Rabot, Magali
AU - Tabiasco, Julie
AU - Polgar, Beata
AU - Aguerre-Girr, Maryse
AU - Berrebi, Alain
AU - Bensussan, Armand
AU - Strbo, Natasa
AU - Rukavina, Daniel
AU - Le Bouteiller, Philippe
PY - 2006
Y1 - 2006
N2 - Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major subpopulation of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy expresses the polymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response.
AB - Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major subpopulation of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy expresses the polymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response.
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M3 - Review article
C2 - 16129954
AN - SCOPUS:27244449802
VL - 89
SP - 72
EP - 83
JO - Progress in Allergy
JF - Progress in Allergy
SN - 1660-2242
ER -