HLA class I/NK cell receptor interaction in early human decidua basalis: Possible functional consequences

Magali Rabot, Julie Tabiasco, Beata Polgar, Maryse Aguerre-Girr, Alain Berrebi, Armand Bensussan, Natasa Strbo, Daniel Rukavina, Philippe Le Bouteiller

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20 Scopus citations

Abstract

Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major subpopulation of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy expresses the polymorphic HLA-C, and nonpolymorphic HLA-E and HLA-G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the antiviral immune response.

Original languageEnglish (US)
Pages (from-to)72-83
Number of pages12
JournalChemical Immunology and Allergy
Volume89
StatePublished - 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Rabot, M., Tabiasco, J., Polgar, B., Aguerre-Girr, M., Berrebi, A., Bensussan, A., Strbo, N., Rukavina, D., & Le Bouteiller, P. (2006). HLA class I/NK cell receptor interaction in early human decidua basalis: Possible functional consequences. Chemical Immunology and Allergy, 89, 72-83.