HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene

T. L. Garber, S. N. McAdam, L. M. Butler, P. Crocker, M. Piekarczyk, G. M. Troup, E. L. Milford, David Watkins

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalTissue Antigens
Volume47
Issue number2
StatePublished - Mar 8 1996
Externally publishedYes

Fingerprint

HLA-B Antigens
Alleles
Population Groups
North American Indians
South America
North America
Population

Keywords

  • HLA-B locus alleles
  • North and South American Amerindian

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

Cite this

Garber, T. L., McAdam, S. N., Butler, L. M., Crocker, P., Piekarczyk, M., Troup, G. M., ... Watkins, D. (1996). HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene. Tissue Antigens, 47(2), 143-146.

HLA-B alleles of the Navajo : No evidence for rapid evolution in the Nadene. / Garber, T. L.; McAdam, S. N.; Butler, L. M.; Crocker, P.; Piekarczyk, M.; Troup, G. M.; Milford, E. L.; Watkins, David.

In: Tissue Antigens, Vol. 47, No. 2, 08.03.1996, p. 143-146.

Research output: Contribution to journalArticle

Garber, TL, McAdam, SN, Butler, LM, Crocker, P, Piekarczyk, M, Troup, GM, Milford, EL & Watkins, D 1996, 'HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene', Tissue Antigens, vol. 47, no. 2, pp. 143-146.
Garber TL, McAdam SN, Butler LM, Crocker P, Piekarczyk M, Troup GM et al. HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene. Tissue Antigens. 1996 Mar 8;47(2):143-146.
Garber, T. L. ; McAdam, S. N. ; Butler, L. M. ; Crocker, P. ; Piekarczyk, M. ; Troup, G. M. ; Milford, E. L. ; Watkins, David. / HLA-B alleles of the Navajo : No evidence for rapid evolution in the Nadene. In: Tissue Antigens. 1996 ; Vol. 47, No. 2. pp. 143-146.
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