Abstract
New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-146 |
| Number of pages | 4 |
| Journal | Tissue Antigens |
| Volume | 47 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 1 1996 |
| Externally published | Yes |
Keywords
- HLA-B locus alleles
- North and South American Amerindian
ASJC Scopus subject areas
- Immunology
- Cell Biology
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Garber, T. L., McAdam, S. N., Butler, L. M., Crocker, P., Piekarczyk, M., Troup, G. M., Milford, E. L., & Watkins, D. I. (1996). HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene. Tissue Antigens, 47(2), 143-146. https://doi.org/10.1111/j.1399-0039.1996.tb02528.x