HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene

T. L. Garber, S. N. McAdam, L. M. Butler, P. Crocker, M. Piekarczyk, G. M. Troup, E. L. Milford, D. I. Watkins

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalTissue Antigens
Issue number2
StatePublished - 1996
Externally publishedYes


  • HLA-B locus alleles
  • North and South American Amerindian

ASJC Scopus subject areas

  • Immunology
  • Cell Biology


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