HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene

T. L. Garber; S. N. McAdam; L. M. Butler; P. Crocker; M. Piekarczyk; G. M. Troup; E. L. Milford; D. I. Watkins

doi:10.1111/j.1399-0039.1996.tb02528.x

HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene

T. L. Garber, S. N. McAdam, L. M. Butler, P. Crocker, M. Piekarczyk, G. M. Troup, E. L. Milford, D. I. Watkins

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.

Original language	English (US)
Pages (from-to)	143-146
Number of pages	4
Journal	Tissue Antigens
Volume	47
Issue number	2
DOIs	https://doi.org/10.1111/j.1399-0039.1996.tb02528.x
State	Published - Jan 1 1996
Externally published	Yes

Keywords

HLA-B locus alleles
North and South American Amerindian

ASJC Scopus subject areas

Immunology
Cell Biology

Access to Document

10.1111/j.1399-0039.1996.tb02528.x

Fingerprint Dive into the research topics of 'HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene'. Together they form a unique fingerprint.

Cite this

@article{36971146713945cfb2a84f76647f9f85,

title = "HLA-B alleles of the Navajo: No evidence for rapid evolution in the Nadene",

abstract = "New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.",

keywords = "HLA-B locus alleles, North and South American Amerindian",

author = "Garber, {T. L.} and McAdam, {S. N.} and Butler, {L. M.} and P. Crocker and M. Piekarczyk and Troup, {G. M.} and Milford, {E. L.} and Watkins, {D. I.}",

year = "1996",

month = jan,

day = "1",

doi = "10.1111/j.1399-0039.1996.tb02528.x",

language = "English (US)",

volume = "47",

pages = "143--146",

journal = "HLA",

issn = "2059-2302",

publisher = "Wiley-Blackwell",

number = "2",

}

TY - JOUR

T1 - HLA-B alleles of the Navajo

T2 - No evidence for rapid evolution in the Nadene

AU - Garber, T. L.

AU - McAdam, S. N.

AU - Butler, L. M.

AU - Crocker, P.

AU - Piekarczyk, M.

AU - Troup, G. M.

AU - Milford, E. L.

AU - Watkins, D. I.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.

AB - New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.

KW - HLA-B locus alleles

KW - North and South American Amerindian

UR - http://www.scopus.com/inward/record.url?scp=0030042011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030042011&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0039.1996.tb02528.x

DO - 10.1111/j.1399-0039.1996.tb02528.x

M3 - Article

C2 - 8851729

AN - SCOPUS:0030042011

VL - 47

SP - 143

EP - 146

JO - HLA

JF - HLA

SN - 2059-2302

IS - 2

ER -