Abstract
New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.
| Original language | English |
|---|---|
| Pages (from-to) | 143-146 |
| Number of pages | 4 |
| Journal | Tissue Antigens |
| Volume | 47 |
| Issue number | 2 |
| State | Published - Mar 8 1996 |
| Externally published | Yes |
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Keywords
- HLA-B locus alleles
- North and South American Amerindian
ASJC Scopus subject areas
- Immunology
- Cell Biology
Cite this
HLA-B alleles of the Navajo : No evidence for rapid evolution in the Nadene. / Garber, T. L.; McAdam, S. N.; Butler, L. M.; Crocker, P.; Piekarczyk, M.; Troup, G. M.; Milford, E. L.; Watkins, David.
In: Tissue Antigens, Vol. 47, No. 2, 08.03.1996, p. 143-146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HLA-B alleles of the Navajo
T2 - No evidence for rapid evolution in the Nadene
AU - Garber, T. L.
AU - McAdam, S. N.
AU - Butler, L. M.
AU - Crocker, P.
AU - Piekarczyk, M.
AU - Troup, G. M.
AU - Milford, E. L.
AU - Watkins, David
PY - 1996/3/8
Y1 - 1996/3/8
N2 - New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.
AB - New HLA-B locus alleles have been found in South American Amerindian populations but were largely absent in North American Amerindian tribes also descended from this first Paleo-Indian migration. We have now extended these studies to the Navajo, descendants of the second Nadene migration. No new functional alleles were found at the B locus of this tribe. This limited study supports the notion that while new B locus variants are common in South American Amerindians, it is more difficult to find new B locus alleles in North American native peoples. Whether this dichotomy is due to differences in pathogen environment and/or population structures between North and South America remains a subject of speculation.
KW - HLA-B locus alleles
KW - North and South American Amerindian
UR - http://www.scopus.com/inward/record.url?scp=0030042011&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030042011&partnerID=8YFLogxK
M3 - Article
C2 - 8851729
AN - SCOPUS:0030042011
VL - 47
SP - 143
EP - 146
JO - HLA
JF - HLA
SN - 2059-2302
IS - 2
ER -