HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia

Janet L Davis, K. K. Mittal, V. Freidlin, S. R. Mellow, D. C. Optican, A. G. Palestine, R. B. Nussenblatt

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Abstract

A strong association with HLA antigens DR4, DRw53, and Bw54 has previously been reported among Japanese patients with Vogt-Koyanagi-Harada disease (VKH) and sympathetic ophthalmia (SO). In the United States, no firm association between HLA-A or -B loci and VKH has been found previously; testing for HLA-DR loci has not been performed to date. The authors performed HLA typing of 23 American patients with VKH and 8 patients with SO. When VKH patients were compared with racially matched controls without disease and patients with other types of uveitis, strong associations with HLA-DR4 and HLA-DRw53 were found. The strongest associations observed in this sample were with HLA-DQw3, an antigen which is in positive linkage disequilibrium with DR4, and with the HLA-DR4/DQw3 haplotype. The small number of patients with SO precluded statistical analysis; however, similar HLA associations were noted. The patients also were questioned regarding their ancestry. The anecdotal association of VKH with American Indian ancestry was confirmed. It appears that the ethnoracial association may be explined by HLA type. One possible explanation for identical HLA associations in two diseases with different precipitating events yet similar ocular manifestations is development of an altered immune response to exogenous microbial antigen with subsequent autoimmunity. Further definition of the genetic susceptibility to VKH and SO may help define the pathophysiology of both diseases and allow the prediction of which patients are at increased risk for SO.

Original languageEnglish
Pages (from-to)1137-1142
Number of pages6
JournalOphthalmology
Volume97
Issue number9
StatePublished - Jan 1 1990

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Sympathetic Ophthalmia
Uveomeningoencephalitic Syndrome
HLA-DR4 Antigen
Eye Manifestations
Histocompatibility Testing
HLA-A Antigens
North American Indians
Uveitis
Linkage Disequilibrium
HLA-DR Antigens
Genetic Predisposition to Disease
HLA Antigens
Autoimmunity
Haplotypes
Antigens

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Davis, J. L., Mittal, K. K., Freidlin, V., Mellow, S. R., Optican, D. C., Palestine, A. G., & Nussenblatt, R. B. (1990). HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. Ophthalmology, 97(9), 1137-1142.

HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. / Davis, Janet L; Mittal, K. K.; Freidlin, V.; Mellow, S. R.; Optican, D. C.; Palestine, A. G.; Nussenblatt, R. B.

In: Ophthalmology, Vol. 97, No. 9, 01.01.1990, p. 1137-1142.

Research output: Contribution to journalArticle

Davis, JL, Mittal, KK, Freidlin, V, Mellow, SR, Optican, DC, Palestine, AG & Nussenblatt, RB 1990, 'HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia', Ophthalmology, vol. 97, no. 9, pp. 1137-1142.
Davis JL, Mittal KK, Freidlin V, Mellow SR, Optican DC, Palestine AG et al. HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. Ophthalmology. 1990 Jan 1;97(9):1137-1142.
Davis, Janet L ; Mittal, K. K. ; Freidlin, V. ; Mellow, S. R. ; Optican, D. C. ; Palestine, A. G. ; Nussenblatt, R. B. / HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. In: Ophthalmology. 1990 ; Vol. 97, No. 9. pp. 1137-1142.
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