HLA antigens and corticosteroid response

Bernard Becker; Dong H. Shin; Paul F. Palmberg; Stephen R. Waltman

doi:10.1126/science.1006308

HLA antigens and corticosteroid response

Bernard Becker, Dong H. Shin, Paul F. Palmberg, Stephen R. Waltman

Research output: Contribution to journal › Article

30 Scopus citations

Abstract

Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.

Original language	English (US)
Pages (from-to)	1427-1428
Number of pages	2
Journal	Science
Volume	194
Issue number	4272
DOIs	https://doi.org/10.1126/science.1006308
State	Published - Jan 1 1976
Externally published	Yes

ASJC Scopus subject areas

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Becker, B., Shin, D. H., Palmberg, P. F., & Waltman, S. R. (1976). HLA antigens and corticosteroid response. Science, 194(4272), 1427-1428. https://doi.org/10.1126/science.1006308

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abstract = "Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.",

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AB - Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.

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