HLA antigens and corticosteroid response

Bernard Becker; Dong H. Shin; Paul F. Palmberg; Stephen R. Waltman

doi:10.1126/science.1006308

HLA antigens and corticosteroid response

Bernard Becker, Dong H. Shin, Paul F. Palmberg, Stephen R. Waltman

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.

Original language	English (US)
Pages (from-to)	1427-1428
Number of pages	2
Journal	Science
Volume	194
Issue number	4272
DOIs	https://doi.org/10.1126/science.1006308
State	Published - 1976
Externally published	Yes

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@article{a18f69c82ac64309bb27f53d9e275b94,

title = "HLA antigens and corticosteroid response",

abstract = "Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.",

author = "Bernard Becker and Shin, {Dong H.} and Palmberg, {Paul F.} and Waltman, {Stephen R.}",

year = "1976",

doi = "10.1126/science.1006308",

language = "English (US)",

volume = "194",

pages = "1427--1428",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "4272",

}

TY - JOUR

T1 - HLA antigens and corticosteroid response

AU - Becker, Bernard

AU - Shin, Dong H.

AU - Palmberg, Paul F.

AU - Waltman, Stephen R.

PY - 1976

Y1 - 1976

N2 - Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.

AB - Compared with normal individuals, patients with primary open angle glaucoma have increased prevalences of HLA B12 and B7 antigens and are more responsive to glucocorticoids. Lymphocytes from both ocular normotensive and glaucomatous individuals with the HLA B12 antigen require significantly (P<.02) lower concentrations of prednisolone to inhibit phytohemagglutinin induced transformation.

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U2 - 10.1126/science.1006308

DO - 10.1126/science.1006308

M3 - Article

C2 - 1006308

AN - SCOPUS:0017146865

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SP - 1427

EP - 1428

JO - Science

JF - Science

SN - 0036-8075

IS - 4272

ER -

HLA antigens and corticosteroid response

Abstract

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