HIV nuclear import: What's the flap?

Mario Stevenson

doi:10.1038/76191

HIV nuclear import: What's the flap?

Mario Stevenson

Research output: Contribution to journal › Short survey › peer-review

32 Scopus citations

Abstract

Elucidation of the mechanisms behind nuclear translocation of viral nucleic acids will lead to improvements in the design of anti-retroviral drugs and gene therapy vectors that are able to transduce non-dividing cells. A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription, or a 'central DNA flap,' as a component of HIV nuclear import.

Original language	English (US)
Pages (from-to)	626-628
Number of pages	3
Journal	Nature medicine
Volume	6
Issue number	6
DOIs	https://doi.org/10.1038/76191
State	Published - Jun 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Elucidation of the mechanisms behind nuclear translocation of viral nucleic acids will lead to improvements in the design of anti-retroviral drugs and gene therapy vectors that are able to transduce non-dividing cells. A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription, or a 'central DNA flap,' as a component of HIV nuclear import.",

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HIV nuclear import: What's the flap?

Abstract

ASJC Scopus subject areas

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