HIV nuclear import: What's the flap?

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Elucidation of the mechanisms behind nuclear translocation of viral nucleic acids will lead to improvements in the design of anti-retroviral drugs and gene therapy vectors that are able to transduce non-dividing cells. A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription, or a 'central DNA flap,' as a component of HIV nuclear import.

Original languageEnglish
Pages (from-to)626-628
Number of pages3
JournalNature Medicine
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2000
Externally publishedYes

Fingerprint

Drug therapy
Gene therapy
Cell Nucleus Active Transport
Transcription
Nucleic Acids
Complementary DNA
HIV
DNA
Genetic Therapy
Reverse Transcription
Drug Therapy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

HIV nuclear import : What's the flap? / Stevenson, Mario.

In: Nature Medicine, Vol. 6, No. 6, 01.06.2000, p. 626-628.

Research output: Contribution to journalArticle

Stevenson, Mario. / HIV nuclear import : What's the flap?. In: Nature Medicine. 2000 ; Vol. 6, No. 6. pp. 626-628.
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