HIV nuclear import: What's the flap?

Research output: Contribution to journalShort survey

31 Scopus citations

Abstract

Elucidation of the mechanisms behind nuclear translocation of viral nucleic acids will lead to improvements in the design of anti-retroviral drugs and gene therapy vectors that are able to transduce non-dividing cells. A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription, or a 'central DNA flap,' as a component of HIV nuclear import.

Original languageEnglish (US)
Pages (from-to)626-628
Number of pages3
JournalNature medicine
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2000

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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