HIV infection of human choroid plexus: A possible mechanism of viral entry into the CNS

M. F. Falangola, A. Hanly, B. Galvao-Castro, Carol Petito

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

The present study examines the hypothesis that HIV infection of the choroid plexus (CPx) may be an important site of vital entry into the brain. Formalin-fixed, paraffin-embedded CPx was obtained from 25 patients with AIDS and 13 nonAIDS patients and was processed for light microscopy and for immunohistochemical detection of HIV gp41, T and B lymphocytes, monocytes/macrophages and endothelial cells. Eleven of the 13 nonAIDS CPx were normal and 2 contained inflammatory foci of undetermined etiology. The stroma contained T lymphocytes in all and monocytes in 22%; B lymphocytes and HIV antigen were absent. Choroid plexus of the AIDS cases contained opportunistic infections or lymphoma in 12 and inflammatory foci alone in 6; 7 were normal. T lymphocytes were present in 70% and monocytes in 50%. In addition to the stromal localization, monocytes also were present in supra epithelial regions and within or adjacent to the capillary endothelium. HIV- positive cells in the CPx were found in 11 cases (44%) and in the supra- epithelial area in another 2. Their presence correlated with neither infection nor lymphoma of the CPx or brain. They were situated in the stroma, supra-epithelial region and (rarely) capillary endothelium. Immunohistochemistry on serial sections identified the HIV-infected cells as monocytes, including those by capillary endothelium and in supra-epithelial areas. The study demonstrates that the CPx contains HIV-infected monocytes in almost half of the cases. Their apposition to endothelium suggests hematogenous origin. These results support the hypothesis that HIV encephalitis may develop from CPx infection.

Original languageEnglish
Pages (from-to)497-503
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume54
Issue number4
StatePublished - Jan 1 1995

Fingerprint

Choroid Plexus
HIV Infections
Monocytes
Vascular Endothelium
HIV
T-Lymphocytes
Lymphoma
HIV Envelope Protein gp41
Acquired Immunodeficiency Syndrome
B-Lymphocytes
HIV Antigens
Opportunistic Infections
Brain
Encephalitis
Infection
Paraffin
Formaldehyde
Endothelium
Microscopy
Endothelial Cells

Keywords

  • AIDS
  • Brain
  • Choroid plexus
  • Encephalitis
  • HIV

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

HIV infection of human choroid plexus : A possible mechanism of viral entry into the CNS. / Falangola, M. F.; Hanly, A.; Galvao-Castro, B.; Petito, Carol.

In: Journal of Neuropathology and Experimental Neurology, Vol. 54, No. 4, 01.01.1995, p. 497-503.

Research output: Contribution to journalArticle

Falangola, MF, Hanly, A, Galvao-Castro, B & Petito, C 1995, 'HIV infection of human choroid plexus: A possible mechanism of viral entry into the CNS', Journal of Neuropathology and Experimental Neurology, vol. 54, no. 4, pp. 497-503.
Falangola, M. F. ; Hanly, A. ; Galvao-Castro, B. ; Petito, Carol. / HIV infection of human choroid plexus : A possible mechanism of viral entry into the CNS. In: Journal of Neuropathology and Experimental Neurology. 1995 ; Vol. 54, No. 4. pp. 497-503.
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