HIV antigen and DNA in AIDS spinal cords correlate with macrophage infiltration but not with vacuolar myelopathy

Carol Petito, Darleen Vecchio, Yao Tseng Chen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Since the relationship between vacuolar myelopathy (VM) and HIV infection of the spinal cord is unclear, we studied 74 cases of VM in AIDS patients for associated spinal cord and brain diseases, the presence of HIV antigens (n = 54) and amplified DNA (n = 7) and serum levels of vitamin B12 and folic acid (n = 6). Necrosis of the medial F. gracilis was present in 14%, HIV myelitis in 9%, cytomegalovirus myelitis in 3% and microglial nodules in 16%. HIV-immunoreactive macrophages were encountered in 6% of VM cords; they were in regions of gracile tract necrosis in two and in monocytes and multinucleated cells in spinal gray matter in one. Amplified HIV DNA was detected in 50% of cords and 70% of dorsal root ganglia (DRG) of cases with moderate or severe VM and 63% of cords and 75% of DRG in AIDS cases without VM. Six of the eight spinal cords with HIV DNA contained macrophages whereas all cords without HIV DNA (n = 6) were normal or contained only rare macrophages. There was no association between VM and HIV myelitis or opportunistic infections of the CNS, but there was a close association with HIV encephalitis which occurred in 80% of severe VM, 33% of moderate VM and 17% of mild VM. Vitamin B12 and folic acid levels were normal or elevated in all six AIDS with VM as well as in 12 AIDS without VM; all had received prophylactic vitamin therapy prior to death. The results show a good correlation between macrophage infiltration and HIV antigens and DNA but little association between VM and HIV myelitis, HIV antigens or HIV DNA. In addition, HIV encephalitis closely correlated with severe VM. The association with HIV encephalitis may be fortuitous since both diseases usually occur during the late stages of AIDS or may indicate an indirect effect of HIV encephalitis upon the spinal cord.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalJournal of Neuropathology and Experimental Neurology
Volume53
Issue number1
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

HIV Antigens
Spinal Cord Diseases
Spinal Cord
Acquired Immunodeficiency Syndrome
Macrophages
HIV
DNA
Myelitis
Encephalitis
Spinal Ganglia
Vitamin B 12
Folic Acid
HIV Infections
Necrosis
Opportunistic Infections
Brain Diseases

Keywords

  • AIDS
  • HIV
  • Immunohistochemistry
  • Polymerase chain reaction
  • Spinal cord
  • Vacuolar myelopathy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

HIV antigen and DNA in AIDS spinal cords correlate with macrophage infiltration but not with vacuolar myelopathy. / Petito, Carol; Vecchio, Darleen; Chen, Yao Tseng.

In: Journal of Neuropathology and Experimental Neurology, Vol. 53, No. 1, 01.01.1994, p. 86-94.

Research output: Contribution to journalArticle

@article{3998c74bf04847df8e9d09a07a06db24,
title = "HIV antigen and DNA in AIDS spinal cords correlate with macrophage infiltration but not with vacuolar myelopathy",
abstract = "Since the relationship between vacuolar myelopathy (VM) and HIV infection of the spinal cord is unclear, we studied 74 cases of VM in AIDS patients for associated spinal cord and brain diseases, the presence of HIV antigens (n = 54) and amplified DNA (n = 7) and serum levels of vitamin B12 and folic acid (n = 6). Necrosis of the medial F. gracilis was present in 14{\%}, HIV myelitis in 9{\%}, cytomegalovirus myelitis in 3{\%} and microglial nodules in 16{\%}. HIV-immunoreactive macrophages were encountered in 6{\%} of VM cords; they were in regions of gracile tract necrosis in two and in monocytes and multinucleated cells in spinal gray matter in one. Amplified HIV DNA was detected in 50{\%} of cords and 70{\%} of dorsal root ganglia (DRG) of cases with moderate or severe VM and 63{\%} of cords and 75{\%} of DRG in AIDS cases without VM. Six of the eight spinal cords with HIV DNA contained macrophages whereas all cords without HIV DNA (n = 6) were normal or contained only rare macrophages. There was no association between VM and HIV myelitis or opportunistic infections of the CNS, but there was a close association with HIV encephalitis which occurred in 80{\%} of severe VM, 33{\%} of moderate VM and 17{\%} of mild VM. Vitamin B12 and folic acid levels were normal or elevated in all six AIDS with VM as well as in 12 AIDS without VM; all had received prophylactic vitamin therapy prior to death. The results show a good correlation between macrophage infiltration and HIV antigens and DNA but little association between VM and HIV myelitis, HIV antigens or HIV DNA. In addition, HIV encephalitis closely correlated with severe VM. The association with HIV encephalitis may be fortuitous since both diseases usually occur during the late stages of AIDS or may indicate an indirect effect of HIV encephalitis upon the spinal cord.",
keywords = "AIDS, HIV, Immunohistochemistry, Polymerase chain reaction, Spinal cord, Vacuolar myelopathy",
author = "Carol Petito and Darleen Vecchio and Chen, {Yao Tseng}",
year = "1994",
month = "1",
day = "1",
language = "English",
volume = "53",
pages = "86--94",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - HIV antigen and DNA in AIDS spinal cords correlate with macrophage infiltration but not with vacuolar myelopathy

AU - Petito, Carol

AU - Vecchio, Darleen

AU - Chen, Yao Tseng

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Since the relationship between vacuolar myelopathy (VM) and HIV infection of the spinal cord is unclear, we studied 74 cases of VM in AIDS patients for associated spinal cord and brain diseases, the presence of HIV antigens (n = 54) and amplified DNA (n = 7) and serum levels of vitamin B12 and folic acid (n = 6). Necrosis of the medial F. gracilis was present in 14%, HIV myelitis in 9%, cytomegalovirus myelitis in 3% and microglial nodules in 16%. HIV-immunoreactive macrophages were encountered in 6% of VM cords; they were in regions of gracile tract necrosis in two and in monocytes and multinucleated cells in spinal gray matter in one. Amplified HIV DNA was detected in 50% of cords and 70% of dorsal root ganglia (DRG) of cases with moderate or severe VM and 63% of cords and 75% of DRG in AIDS cases without VM. Six of the eight spinal cords with HIV DNA contained macrophages whereas all cords without HIV DNA (n = 6) were normal or contained only rare macrophages. There was no association between VM and HIV myelitis or opportunistic infections of the CNS, but there was a close association with HIV encephalitis which occurred in 80% of severe VM, 33% of moderate VM and 17% of mild VM. Vitamin B12 and folic acid levels were normal or elevated in all six AIDS with VM as well as in 12 AIDS without VM; all had received prophylactic vitamin therapy prior to death. The results show a good correlation between macrophage infiltration and HIV antigens and DNA but little association between VM and HIV myelitis, HIV antigens or HIV DNA. In addition, HIV encephalitis closely correlated with severe VM. The association with HIV encephalitis may be fortuitous since both diseases usually occur during the late stages of AIDS or may indicate an indirect effect of HIV encephalitis upon the spinal cord.

AB - Since the relationship between vacuolar myelopathy (VM) and HIV infection of the spinal cord is unclear, we studied 74 cases of VM in AIDS patients for associated spinal cord and brain diseases, the presence of HIV antigens (n = 54) and amplified DNA (n = 7) and serum levels of vitamin B12 and folic acid (n = 6). Necrosis of the medial F. gracilis was present in 14%, HIV myelitis in 9%, cytomegalovirus myelitis in 3% and microglial nodules in 16%. HIV-immunoreactive macrophages were encountered in 6% of VM cords; they were in regions of gracile tract necrosis in two and in monocytes and multinucleated cells in spinal gray matter in one. Amplified HIV DNA was detected in 50% of cords and 70% of dorsal root ganglia (DRG) of cases with moderate or severe VM and 63% of cords and 75% of DRG in AIDS cases without VM. Six of the eight spinal cords with HIV DNA contained macrophages whereas all cords without HIV DNA (n = 6) were normal or contained only rare macrophages. There was no association between VM and HIV myelitis or opportunistic infections of the CNS, but there was a close association with HIV encephalitis which occurred in 80% of severe VM, 33% of moderate VM and 17% of mild VM. Vitamin B12 and folic acid levels were normal or elevated in all six AIDS with VM as well as in 12 AIDS without VM; all had received prophylactic vitamin therapy prior to death. The results show a good correlation between macrophage infiltration and HIV antigens and DNA but little association between VM and HIV myelitis, HIV antigens or HIV DNA. In addition, HIV encephalitis closely correlated with severe VM. The association with HIV encephalitis may be fortuitous since both diseases usually occur during the late stages of AIDS or may indicate an indirect effect of HIV encephalitis upon the spinal cord.

KW - AIDS

KW - HIV

KW - Immunohistochemistry

KW - Polymerase chain reaction

KW - Spinal cord

KW - Vacuolar myelopathy

UR - http://www.scopus.com/inward/record.url?scp=0027976316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027976316&partnerID=8YFLogxK

M3 - Article

VL - 53

SP - 86

EP - 94

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 1

ER -