HIV and carotid atherosclerosis: a mediational model

Maria Luisa Alcaide, Violeta J. Rodriguez, John M. Abbamonte, Suresh Pallikuth, Jake Langlie, Manasi Soni, Stephen M. Weiss, Barry E. Hurwitz, Savita Pahwa, Deborah L. Jones, Mahendra Kumar

Research output: Contribution to journalArticle

Abstract

Cardiovascular disease (CVD) is the leading cause of death in the US and is a significant contributor to morbidity and mortality for people living with HIV (PLWH). This study examined the association between HIV infection, cocaine usage, and inflammatory markers, and their combined association with carotid atherosclerosis among young and middle-aged adults with HIV. Participants (N = 494) were enrolled based on HIV status and cocaine use. Blood pressure, body mass index (BMI), and cocaine use were assessed. Cytokines and growth factors, IL-1a, IL-6, TNFα and VEGF, and immune activation markers, sCD14 and sCD163 were measured. Participant age was 36.2 years (SD = 9.5); 50% were male, 49% female and 1% transgender; 39% were HIV-positive, 50% were current or past smokers, and 39% endorsed cocaine use. A path analysis showed an indirect effect of HIV serostatus on the presence of carotid atherosclerotic plaques (Indirect Effect = 0.048, SE = 0.024, p =.043), when controlling age, BMI, smoking, and cocaine use. This effect was mediated by inflammatory markers and changes in blood pressure. Findings point to putative underlying mechanisms leading to atherosclerosis among PLWH.

Original languageEnglish (US)
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
DOIs
StateAccepted/In press - Jan 1 2019

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Carotid Artery Diseases
Cocaine
HIV
path analysis
cause of death
morbidity
activation
smoking
Body Mass Index
mortality
Transgender Persons
Blood Pressure
Disease
Atherosclerotic Plaques
Vascular Endothelial Growth Factor A
HIV Infections
Cause of Death
Interleukin-6
Atherosclerosis
Intercellular Signaling Peptides and Proteins

Keywords

  • Atherosclerosis
  • cocaine
  • HIV
  • immune activation
  • inflammation

ASJC Scopus subject areas

  • Social Psychology
  • Health(social science)
  • Public Health, Environmental and Occupational Health

Cite this

HIV and carotid atherosclerosis : a mediational model. / Alcaide, Maria Luisa; Rodriguez, Violeta J.; Abbamonte, John M.; Pallikuth, Suresh; Langlie, Jake; Soni, Manasi; Weiss, Stephen M.; Hurwitz, Barry E.; Pahwa, Savita; Jones, Deborah L.; Kumar, Mahendra.

In: AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV, 01.01.2019.

Research output: Contribution to journalArticle

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