HIV-1 neuropathogenesis and abused drugs

Current views, problems, and solutions

P. Shapshak, K. A. Crandall, K. Q. Xin, K. Goodkin, R. K. Fujimura, Walter G Bradley, Clyde B McCoy, I. Nagano, M. Yoshioka, Carol Petito, N. C J Sun, A. K. Srivastava, N. Weatherby, R. Stewart, Silvia Delgado, A. Matthews, R. Douyon, K. Okuda, J. Yang, B. T. Zhangl & 5 others X. R. Cao, S. Shatkovsky, J. B. Fernandez, S. M. Shah, J. Perper

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

HIV Associated Dementia (HAD) and peripheral neuropathy result from HIV- 1 infection and several parameters impact on their initiation and course. These parameters include properties of the virus such as sequence heterogeneity of the envelope protein and virus and host gene expression in infected and uninfected macrophages in HIV infected individuals. The infection of brain cells such as macrophage/microglia may influence the course and duration of HAD through the elaboration of toxic molecules and viral host by-products of infection. Drugs of abuse complicate our interpretation of the resulting pathologies and affect the molecular and biochemical processes involved in HIV-1 infection and its life cycle. Furthermore, abused drugs may modulate the biology and function of macrophage/microglia as well as other cells in brain. Total HIV-1 virus load in the brain may also impact the clinical consequences of infection. Although specific strains of HIV-1 may inflict HAD by interactions at the molecular level, other mechanisms may operate in the initiation and development of peripheral neuropathy. An important aspect of these studies is the determination of their accuracy, specificity, sensitivity, and reproducibility. We describe important caveats involved in the performance, analysis, and interpretation of the results.

Original languageEnglish
Pages (from-to)171-186
Number of pages16
JournalAdvances in Experimental Medicine and Biology
Volume402
StatePublished - Oct 2 1996

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Macrophages
AIDS Dementia Complex
HIV-1
Brain
Viruses
Microglia
Peripheral Nervous System Diseases
Pharmaceutical Preparations
Viral Envelope Proteins
HIV Infections
Biochemical Phenomena
Infection
Poisons
Street Drugs
Pathology
Gene expression
Byproducts
Molecular Pathology
Life cycle
Life Cycle Stages

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Shapshak, P., Crandall, K. A., Xin, K. Q., Goodkin, K., Fujimura, R. K., Bradley, W. G., ... Perper, J. (1996). HIV-1 neuropathogenesis and abused drugs: Current views, problems, and solutions. Advances in Experimental Medicine and Biology, 402, 171-186.

HIV-1 neuropathogenesis and abused drugs : Current views, problems, and solutions. / Shapshak, P.; Crandall, K. A.; Xin, K. Q.; Goodkin, K.; Fujimura, R. K.; Bradley, Walter G; McCoy, Clyde B; Nagano, I.; Yoshioka, M.; Petito, Carol; Sun, N. C J; Srivastava, A. K.; Weatherby, N.; Stewart, R.; Delgado, Silvia; Matthews, A.; Douyon, R.; Okuda, K.; Yang, J.; Zhangl, B. T.; Cao, X. R.; Shatkovsky, S.; Fernandez, J. B.; Shah, S. M.; Perper, J.

In: Advances in Experimental Medicine and Biology, Vol. 402, 02.10.1996, p. 171-186.

Research output: Contribution to journalArticle

Shapshak, P, Crandall, KA, Xin, KQ, Goodkin, K, Fujimura, RK, Bradley, WG, McCoy, CB, Nagano, I, Yoshioka, M, Petito, C, Sun, NCJ, Srivastava, AK, Weatherby, N, Stewart, R, Delgado, S, Matthews, A, Douyon, R, Okuda, K, Yang, J, Zhangl, BT, Cao, XR, Shatkovsky, S, Fernandez, JB, Shah, SM & Perper, J 1996, 'HIV-1 neuropathogenesis and abused drugs: Current views, problems, and solutions', Advances in Experimental Medicine and Biology, vol. 402, pp. 171-186.
Shapshak, P. ; Crandall, K. A. ; Xin, K. Q. ; Goodkin, K. ; Fujimura, R. K. ; Bradley, Walter G ; McCoy, Clyde B ; Nagano, I. ; Yoshioka, M. ; Petito, Carol ; Sun, N. C J ; Srivastava, A. K. ; Weatherby, N. ; Stewart, R. ; Delgado, Silvia ; Matthews, A. ; Douyon, R. ; Okuda, K. ; Yang, J. ; Zhangl, B. T. ; Cao, X. R. ; Shatkovsky, S. ; Fernandez, J. B. ; Shah, S. M. ; Perper, J. / HIV-1 neuropathogenesis and abused drugs : Current views, problems, and solutions. In: Advances in Experimental Medicine and Biology. 1996 ; Vol. 402. pp. 171-186.
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