HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes

Mahendra Kumar, K. Goodkin, Adarsh Kumar, T. T. Baldewicz, R. Morgan, C. Eisdorfer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Different lines of evidence suggest that human immunodeficiency virus type 1 (HIV-1) infection is complicated by a variety of adverse effects on neuroendocrine systems. Soon after the discovery of HIV-1, reports began to appear suggesting that a number of neurotransmitter and neuroendocrine activities were negatively impacted by this infection. In 1987 it was observed that fine-needle aspiration of the lung in patients with acquired immunodeficiency syndrome resulted in syncopal reactions. Subsequently, an abnormality in the autonomic nervous system was reported in these patients. However, investigations in this area have remained limited due to the assumption that HIV-1-mediated activation of various endocrine systems was related to the major life stressor of living with a fatal disease. Evidence accumulated over the years has indicated, instead, that there are various other mechanisms in addition to life stressors that also play an important role in negatively impacting the neuroendocrine systems in this infection. This article examines various developments that have taken place in this area in order to provide avenues for future research.

Original languageEnglish
Pages (from-to)55-65
Number of pages11
JournalCNS Spectrums
Volume5
Issue number5
StatePublished - Jan 1 2000

Fingerprint

Virus Diseases
HIV-1
Neurosecretory Systems
Endocrine System
Autonomic Nervous System
Fine Needle Biopsy
Infection
Neurotransmitter Agents
Acquired Immunodeficiency Syndrome
Lung

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Kumar, M., Goodkin, K., Kumar, A., Baldewicz, T. T., Morgan, R., & Eisdorfer, C. (2000). HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes. CNS Spectrums, 5(5), 55-65.

HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes. / Kumar, Mahendra; Goodkin, K.; Kumar, Adarsh; Baldewicz, T. T.; Morgan, R.; Eisdorfer, C.

In: CNS Spectrums, Vol. 5, No. 5, 01.01.2000, p. 55-65.

Research output: Contribution to journalArticle

Kumar, M, Goodkin, K, Kumar, A, Baldewicz, TT, Morgan, R & Eisdorfer, C 2000, 'HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes', CNS Spectrums, vol. 5, no. 5, pp. 55-65.
Kumar M, Goodkin K, Kumar A, Baldewicz TT, Morgan R, Eisdorfer C. HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes. CNS Spectrums. 2000 Jan 1;5(5):55-65.
Kumar, Mahendra ; Goodkin, K. ; Kumar, Adarsh ; Baldewicz, T. T. ; Morgan, R. ; Eisdorfer, C. / HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes. In: CNS Spectrums. 2000 ; Vol. 5, No. 5. pp. 55-65.
@article{de137fbea9ff45698e395b3616ae758a,
title = "HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes",
abstract = "Different lines of evidence suggest that human immunodeficiency virus type 1 (HIV-1) infection is complicated by a variety of adverse effects on neuroendocrine systems. Soon after the discovery of HIV-1, reports began to appear suggesting that a number of neurotransmitter and neuroendocrine activities were negatively impacted by this infection. In 1987 it was observed that fine-needle aspiration of the lung in patients with acquired immunodeficiency syndrome resulted in syncopal reactions. Subsequently, an abnormality in the autonomic nervous system was reported in these patients. However, investigations in this area have remained limited due to the assumption that HIV-1-mediated activation of various endocrine systems was related to the major life stressor of living with a fatal disease. Evidence accumulated over the years has indicated, instead, that there are various other mechanisms in addition to life stressors that also play an important role in negatively impacting the neuroendocrine systems in this infection. This article examines various developments that have taken place in this area in order to provide avenues for future research.",
author = "Mahendra Kumar and K. Goodkin and Adarsh Kumar and Baldewicz, {T. T.} and R. Morgan and C. Eisdorfer",
year = "2000",
month = "1",
day = "1",
language = "English",
volume = "5",
pages = "55--65",
journal = "CNS Spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "5",

}

TY - JOUR

T1 - HIV-1 infection, neuroendocrine abnormalities, and clinical outcomes

AU - Kumar, Mahendra

AU - Goodkin, K.

AU - Kumar, Adarsh

AU - Baldewicz, T. T.

AU - Morgan, R.

AU - Eisdorfer, C.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Different lines of evidence suggest that human immunodeficiency virus type 1 (HIV-1) infection is complicated by a variety of adverse effects on neuroendocrine systems. Soon after the discovery of HIV-1, reports began to appear suggesting that a number of neurotransmitter and neuroendocrine activities were negatively impacted by this infection. In 1987 it was observed that fine-needle aspiration of the lung in patients with acquired immunodeficiency syndrome resulted in syncopal reactions. Subsequently, an abnormality in the autonomic nervous system was reported in these patients. However, investigations in this area have remained limited due to the assumption that HIV-1-mediated activation of various endocrine systems was related to the major life stressor of living with a fatal disease. Evidence accumulated over the years has indicated, instead, that there are various other mechanisms in addition to life stressors that also play an important role in negatively impacting the neuroendocrine systems in this infection. This article examines various developments that have taken place in this area in order to provide avenues for future research.

AB - Different lines of evidence suggest that human immunodeficiency virus type 1 (HIV-1) infection is complicated by a variety of adverse effects on neuroendocrine systems. Soon after the discovery of HIV-1, reports began to appear suggesting that a number of neurotransmitter and neuroendocrine activities were negatively impacted by this infection. In 1987 it was observed that fine-needle aspiration of the lung in patients with acquired immunodeficiency syndrome resulted in syncopal reactions. Subsequently, an abnormality in the autonomic nervous system was reported in these patients. However, investigations in this area have remained limited due to the assumption that HIV-1-mediated activation of various endocrine systems was related to the major life stressor of living with a fatal disease. Evidence accumulated over the years has indicated, instead, that there are various other mechanisms in addition to life stressors that also play an important role in negatively impacting the neuroendocrine systems in this infection. This article examines various developments that have taken place in this area in order to provide avenues for future research.

UR - http://www.scopus.com/inward/record.url?scp=0033934817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033934817&partnerID=8YFLogxK

M3 - Article

C2 - 18268467

AN - SCOPUS:0033934817

VL - 5

SP - 55

EP - 65

JO - CNS Spectrums

JF - CNS Spectrums

SN - 1092-8529

IS - 5

ER -