HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Abstract

HIV-1 crosses the blood-brain barrier (BBB) early in the course of systemic infection and resides in brain macrophages and microglia. The integrity of the brain endothelium is regulated by intercellular tight junctions, which also play a critical role in HIV-1-entry into the brain. Disruption of tight junctions, including changes in claudin-5 expression, is common in HIV-1-infected patients. Recent evidence indicates that both exposure to HIV-1 and HIV-1 specific proteins, such as Tat protein, can contribute to alterations of expression and distribution of claudin-5 in brain endothelial cells and brain microvessels.

Original languageEnglish (US)
Title of host publicationClaudins
Subtitle of host publicationMethods and Protocols
EditorsKursad Turksen
Pages355-370
Number of pages16
DOIs
StatePublished - Jul 29 2011
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume762
ISSN (Print)1064-3745

Keywords

  • Blood-brain barrier
  • Brain microvascular endothelial cell
  • Claudin-5
  • HIV-1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    András, I. E., & Toborek, M. (2011). HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. In K. Turksen (Ed.), Claudins: Methods and Protocols (pp. 355-370). (Methods in Molecular Biology; Vol. 762). https://doi.org/10.1007/978-1-61779-185-7_26