HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level

Research output: Chapter in Book/Report/Conference proceedingChapter

22 Citations (Scopus)

Abstract

HIV-1 crosses the blood-brain barrier (BBB) early in the course of systemic infection and resides in brain macrophages and microglia. The integrity of the brain endothelium is regulated by intercellular tight junctions, which also play a critical role in HIV-1-entry into the brain. Disruption of tight junctions, including changes in claudin-5 expression, is common in HIV-1-infected patients. Recent evidence indicates that both exposure to HIV-1 and HIV-1 specific proteins, such as Tat protein, can contribute to alterations of expression and distribution of claudin-5 in brain endothelial cells and brain microvessels.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
Pages355-370
Number of pages16
Volume762
DOIs
StatePublished - Jul 29 2011
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume762
ISSN (Print)10643745

Fingerprint

Claudin-5
Blood-Brain Barrier
HIV-1
Brain
Tight Junctions
tat Gene Products
Intercellular Junctions
Microglia
Microvessels
Endothelium
Endothelial Cells
Macrophages
Infection
Proteins

Keywords

  • Blood-brain barrier
  • Brain microvascular endothelial cell
  • Claudin-5
  • HIV-1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Andras, I. E., & Toborek, M. J. (2011). HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. In Methods in Molecular Biology (Vol. 762, pp. 355-370). (Methods in Molecular Biology; Vol. 762). https://doi.org/10.1007/978-1-61779-185-7_26

HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. / Andras, Ibolya Edit; Toborek, Michal J.

Methods in Molecular Biology. Vol. 762 2011. p. 355-370 (Methods in Molecular Biology; Vol. 762).

Research output: Chapter in Book/Report/Conference proceedingChapter

Andras, IE & Toborek, MJ 2011, HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. in Methods in Molecular Biology. vol. 762, Methods in Molecular Biology, vol. 762, pp. 355-370. https://doi.org/10.1007/978-1-61779-185-7_26
Andras, Ibolya Edit ; Toborek, Michal J. / HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level. Methods in Molecular Biology. Vol. 762 2011. pp. 355-370 (Methods in Molecular Biology).
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