HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level

Research output: Chapter in Book/Report/Conference proceedingChapter

25 Scopus citations


HIV-1 crosses the blood-brain barrier (BBB) early in the course of systemic infection and resides in brain macrophages and microglia. The integrity of the brain endothelium is regulated by intercellular tight junctions, which also play a critical role in HIV-1-entry into the brain. Disruption of tight junctions, including changes in claudin-5 expression, is common in HIV-1-infected patients. Recent evidence indicates that both exposure to HIV-1 and HIV-1 specific proteins, such as Tat protein, can contribute to alterations of expression and distribution of claudin-5 in brain endothelial cells and brain microvessels.

Original languageEnglish (US)
Title of host publicationClaudins
Subtitle of host publicationMethods and Protocols
EditorsKursad Turksen
Number of pages16
StatePublished - 2011
Externally publishedYes

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • Blood-brain barrier
  • Brain microvascular endothelial cell
  • Claudin-5
  • HIV-1

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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