Histopathology of wounds

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is difficult to conduct systematic reviews of the literature reporting on histopathology of non-healing chronic wounds since data are mainly from clinical reports and trials. In this chapter the authors summarize their experience of the pathology of chronic wounds and review the available literature to update the current understanding of the pathogenesis of impaired wound healing. Chronic wounds have diverse etiologies some 90% being of venous, pressure and diabetic ulcers. Detailed explanations of their histologic features are provided in this chapter. New immunohistochemical and special stains of potential value for the diagnosis and treatment are discussed. Other less commonly encountered causes for non-healing ulcers include calciphylaxis, radiation ulcers, Pyoderma gangrenosum, factitial ulcers, infections, as well as vasculitis and vasculopathy. Attempts should be made to distinguish vasculitis from vasculopathy as this requires different therapeutic approach as well these two primary vascular diseases from pseudovasculitis and pseudovasculopathy which are common secondary epiphenomena in biopsies from chronic wounds. Finally, to exclude clinical doubts about malignancy in a chronic ulcer, it is essential to sampling of the ulcer at several wound sites (margins and base) and at several time points and to seek a confirmatory tissue diagnosis.

Original languageEnglish (US)
Title of host publicationMeasurements in Wound Healing: Science and Practice
PublisherSpringer-Verlag London Ltd
Pages155-173
Number of pages19
ISBN (Print)9781447129875, 1447129865, 9781447129868
DOIs
StatePublished - Aug 1 2013

Keywords

  • Biopsy
  • Histology
  • Immunohistochemistry
  • Light microscopy
  • Markers
  • Non-healing ulcers
  • Special stains
  • Vasculitis
  • Vasculopathy

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Miteva, M., & Romanelli, P. (2013). Histopathology of wounds. In Measurements in Wound Healing: Science and Practice (pp. 155-173). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2987-5_9