Histopathology of Cerebral Ischemia and Stroke

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Ischemic stroke is a serious neurological problem and one of the leading causes of death and disability worldwide. The histopathological consequences of stroke are complex and may result in a variety of deficits including severe motor and cognitive disturbances. The histopathological consequences of severe focal ischemia are well described with characteristic structural changes occurring in both gray and white brain regions depending on the severity, location, and duration of the ischemic insult. Following focal ischemic injury, neuronal, astrocytic, vascular endothelial, and inflammatory cell changes occur. In white mater tracts, axonal injury with oligodendrocyte damage and subsequent demyelination are also commonly observed. In contrast, less severe or more transient ischemic insults can lead to patterns of selective neuronal injury whereby vulnerable neuronal populations are destroyed without damage to neighboring cells or robust inflammatory responses are induced. The appreciation of these diverse histopathological characteristics associated with periods of cerebral ischemia emphasize the complexity of the pathogenesis of ischemic damage and serve as a basis for drug discovery to identify effective treatments for stroke prevention and treatment.

Original languageEnglish (US)
Title of host publicationPrimer on Cerebrovascular Diseases
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages113-116
Number of pages4
ISBN (Print)9780128030585
DOIs
StatePublished - Mar 7 2017

Fingerprint

Brain Ischemia
Stroke
Wounds and Injuries
Oligodendroglia
Demyelinating Diseases
Vulnerable Populations
Drug Discovery
Cause of Death
Ischemia
Endothelial Cells
Mothers
Brain
Therapeutics

Keywords

  • Astrocytes
  • Blood vessels
  • Inflammation
  • Ischemic stroke
  • Microglia
  • Neurons
  • Oligodendrocytes
  • Penumbra

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Dalton Dietrich, W. (2017). Histopathology of Cerebral Ischemia and Stroke. In Primer on Cerebrovascular Diseases: Second Edition (pp. 113-116). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-803058-5.00022-9

Histopathology of Cerebral Ischemia and Stroke. / Dalton Dietrich, W.

Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., 2017. p. 113-116.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dalton Dietrich, W 2017, Histopathology of Cerebral Ischemia and Stroke. in Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., pp. 113-116. https://doi.org/10.1016/B978-0-12-803058-5.00022-9
Dalton Dietrich W. Histopathology of Cerebral Ischemia and Stroke. In Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc. 2017. p. 113-116 https://doi.org/10.1016/B978-0-12-803058-5.00022-9
Dalton Dietrich, W. / Histopathology of Cerebral Ischemia and Stroke. Primer on Cerebrovascular Diseases: Second Edition. Elsevier Inc., 2017. pp. 113-116
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