Histopathologische Fallstricke der mikrographischen Chirurgie nach Mohs und Übersicht über die Tumorhistologie

Translated title of the contribution: Histopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology

Katlein França, Yasser Alqubaisy, Ashraf Hassanein, Keyvan Nouri, Torello Lotti

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Frozen sections introduce certain artifacts and these artifacts must be interpreted in the correct context. Basal and squamous cell carcinomas are the most common tumors encountered in Mohs micrographic surgery, and their histopathology is also associated with certain “pitfalls”. Basal cell carcinoma should be distinguished from hair follicles, folliculocentric basaloid proliferations, poromas, nevus sebaceous, desmoplastic trichoepitheliomas, and spiradenomas, to name but a few histologic entities. Similarly, squamous cell carcinoma should be distinguished from hypertrophic actinic keratoses, pseudoepitheliomatous hyperplasia, sebaceous carcinoma, and microcystic adnexal carcinoma. In addition, there are numerous subtypes of basal cell and squamous carcinomas that the Mohs surgeon should be aware of due to differences in the biologic behavior of these tumors. This review presents a number of the common histologic pitfalls of Mohs micrographic surgery and a review of tumor histology.

Translated title of the contributionHistopathologic pitfalls of Mohs micrographic surgery and a review of tumor histology
Original languageGerman
Pages (from-to)218-227
Number of pages10
JournalWiener Medizinische Wochenschrift
Issue number9-10
StatePublished - Jun 1 2018


  • Basal cell carcinoma
  • Histopathologic pitfalls
  • Mohs micrographic surgery
  • Squamous cell carcinoma
  • Tumor histology

ASJC Scopus subject areas

  • Medicine(all)


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