Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries

Dennis L. Sprecher, Eileen M. Mikat, Richard Stack, Karen Sutherland, John Schneider, Thomas Bashore, Donald B. Hackel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Reports on vascular pathology post-PTCA in both human and animal coronary vessels have revealed medial and intimal cracks and tears, thrombus formation, platelet accumulation, and loss of endothelial cells. The extent and type of damage can currently be assessed in vivo at the macro level by means of coronary artery angiography. However, this technique cannot define vessel wall characteristics at the cellular level. Our hypothesis is that vessel wall material may adhere to the balloon and thus provide a source for coronary artery cytological investigation in vivo. Ten balloon catheters were evaluated to discern any material which was dislodged from the coronary artery and which remained attached to the balloon catheter or guide wire. Our results indicate that angioplasty catheter balloons frequently have adherent collagen, endothelial cells, organized thrombus, and plaque with obvious cholesterol clefts, that can be retrieved and examined histologically. We conclude that material is often dislodged from the plaque during PTCA. In addition, plaque material removed by the balloon catheter offers an unusual opportunity to analyze the morphologic characteristics of cells from the human coronary artery in vivo.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalAtherosclerosis
Volume75
Issue number2-3
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Balloon Angioplasty
Coronary Vessels
Catheters
Thrombosis
Endothelial Cells
Tunica Intima
Coronary Angiography
Tears
Blood Vessels
Collagen
Blood Platelets
Cholesterol
Pathology

Keywords

  • Angioplasty
  • Atherosclerosis
  • Cytology
  • PTCA

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Sprecher, D. L., Mikat, E. M., Stack, R., Sutherland, K., Schneider, J., Bashore, T., & Hackel, D. B. (1989). Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries. Atherosclerosis, 75(2-3), 237-244. https://doi.org/10.1016/0021-9150(89)90181-0

Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries. / Sprecher, Dennis L.; Mikat, Eileen M.; Stack, Richard; Sutherland, Karen; Schneider, John; Bashore, Thomas; Hackel, Donald B.

In: Atherosclerosis, Vol. 75, No. 2-3, 01.01.1989, p. 237-244.

Research output: Contribution to journalArticle

Sprecher, DL, Mikat, EM, Stack, R, Sutherland, K, Schneider, J, Bashore, T & Hackel, DB 1989, 'Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries', Atherosclerosis, vol. 75, no. 2-3, pp. 237-244. https://doi.org/10.1016/0021-9150(89)90181-0
Sprecher, Dennis L. ; Mikat, Eileen M. ; Stack, Richard ; Sutherland, Karen ; Schneider, John ; Bashore, Thomas ; Hackel, Donald B. / Histopathologic examination of material from angioplasty balloon catheters used in vivo in human coronary arteries. In: Atherosclerosis. 1989 ; Vol. 75, No. 2-3. pp. 237-244.
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