Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse

A. A. Kyriazis, A. P. Kyriazis, J. G. Kereiakes, M. S. Soloway, W. B. McCombs

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
JournalExperimental Cell Biology
Issue number2
StatePublished - May 20 1983

ASJC Scopus subject areas

  • Cell Biology


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