Abstract
The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.
| Original language | English |
|---|---|
| Pages (from-to) | 83-95 |
| Number of pages | 13 |
| Journal | Experimental Cell Biology |
| Volume | 51 |
| Issue number | 2 |
| State | Published - May 20 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
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Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse. / Kyriazis, A. A.; Kyriazis, A. P.; Kereiakes, J. G.; Soloway, M. S.; McCombs, W. B.
In: Experimental Cell Biology, Vol. 51, No. 2, 20.05.1983, p. 83-95.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse
AU - Kyriazis, A. A.
AU - Kyriazis, A. P.
AU - Kereiakes, J. G.
AU - Soloway, M. S.
AU - McCombs, W. B.
PY - 1983/5/20
Y1 - 1983/5/20
N2 - The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.
AB - The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020663135&partnerID=8YFLogxK
M3 - Article
C2 - 6840388
AN - SCOPUS:0020663135
VL - 51
SP - 83
EP - 95
JO - Pathobiology
JF - Pathobiology
SN - 1015-2008
IS - 2
ER -