Abstract
The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-95 |
| Number of pages | 13 |
| Journal | Experimental Cell Biology |
| Volume | 51 |
| Issue number | 2 |
| State | Published - May 20 1983 |
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ASJC Scopus subject areas
- Cell Biology