Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse

A. A. Kyriazis, A. P. Kyriazis, J. G. Kereiakes, M. S. Soloway, W. B. McCombs

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13 Scopus citations

Abstract

The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.

Original languageEnglish (US)
Pages (from-to)83-95
Number of pages13
JournalExperimental Cell Biology
Volume51
Issue number2
StatePublished - May 20 1983

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ASJC Scopus subject areas

  • Cell Biology

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Kyriazis, A. A., Kyriazis, A. P., Kereiakes, J. G., Soloway, M. S., & McCombs, W. B. (1983). Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse. Experimental Cell Biology, 51(2), 83-95.