Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse

A. A. Kyriazis, A. P. Kyriazis, J. G. Kereiakes, M. S. Soloway, W. B. McCombs

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.

Original languageEnglish
Pages (from-to)83-95
Number of pages13
JournalExperimental Cell Biology
Volume51
Issue number2
StatePublished - May 20 1983
Externally publishedYes

Fingerprint

Nude Mice
Neoplasms
Therapeutics
Cell Division
Antineoplastic Agents
Clone Cells
Drug Therapy

ASJC Scopus subject areas

  • Cell Biology

Cite this

Kyriazis, A. A., Kyriazis, A. P., Kereiakes, J. G., Soloway, M. S., & McCombs, W. B. (1983). Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse. Experimental Cell Biology, 51(2), 83-95.

Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse. / Kyriazis, A. A.; Kyriazis, A. P.; Kereiakes, J. G.; Soloway, M. S.; McCombs, W. B.

In: Experimental Cell Biology, Vol. 51, No. 2, 20.05.1983, p. 83-95.

Research output: Contribution to journalArticle

Kyriazis, AA, Kyriazis, AP, Kereiakes, JG, Soloway, MS & McCombs, WB 1983, 'Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse', Experimental Cell Biology, vol. 51, no. 2, pp. 83-95.
Kyriazis AA, Kyriazis AP, Kereiakes JG, Soloway MS, McCombs WB. Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse. Experimental Cell Biology. 1983 May 20;51(2):83-95.
Kyriazis, A. A. ; Kyriazis, A. P. ; Kereiakes, J. G. ; Soloway, M. S. ; McCombs, W. B. / Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse. In: Experimental Cell Biology. 1983 ; Vol. 51, No. 2. pp. 83-95.
@article{e3fbb9a2388a4e6d8b6228cfca03a732,
title = "Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse",
abstract = "The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.",
author = "Kyriazis, {A. A.} and Kyriazis, {A. P.} and Kereiakes, {J. G.} and Soloway, {M. S.} and McCombs, {W. B.}",
year = "1983",
month = "5",
day = "20",
language = "English",
volume = "51",
pages = "83--95",
journal = "Pathobiology",
issn = "1015-2008",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Histopathologic evaluation of response to treatment of human tumors grown in the nude mouse

AU - Kyriazis, A. A.

AU - Kyriazis, A. P.

AU - Kereiakes, J. G.

AU - Soloway, M. S.

AU - McCombs, W. B.

PY - 1983/5/20

Y1 - 1983/5/20

N2 - The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.

AB - The histopathologic changes following chemotherapy treatment of a number of human tumors grown in nude mice were evaluated. On the basis of the histopathologic profile, three response levels were recognized - a mild response, a moderate response and a severe response. Severe response was characterized by arrest of cell division and profound nuclear-cytoplasmic degenerative changes. Regrowth of effectively treated tumors originated in clusters of cells most probably representing resistant tumor cell clones. Histopathologic changes represent a sensitive indicator of the response of nude mouse grown human tumors to anticancer agents. Availability and correct interpretation of the post-treatment histopathologic picture is of importance in selecting the proper combination treatment which would maximize tumor response.

UR - http://www.scopus.com/inward/record.url?scp=0020663135&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020663135&partnerID=8YFLogxK

M3 - Article

VL - 51

SP - 83

EP - 95

JO - Pathobiology

JF - Pathobiology

SN - 1015-2008

IS - 2

ER -