Histopathologic correlation of Aspergillus endophthalmitis following uncomplicated cataract surgery

Luis J. Haddock, Harry W. Flynn, Sander R. Dubovy, Rahul N. Khurana, Peter R. Egbert

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


A clinicopathologic correlation between two patients with acute-onset Aspergillus endophthalmitis undergoing enucleation is reported. These two patients presented with pain, redness, and decreased vision following uncomplicated cataract surgery. In both patients, vitreous aspiration and intravitreal injections were the initial treatment followed later by pars plana vitrectomy for clinical worsening. Despite repeated surgical and medical interventions, the clinical course of both patients was prolonged, unsuccessful, and resulted in enucleation for a blind painful eye. Histologic examination of the enucleated specimens showed that, in spite of prolonged local and systemic therapy, there was persistent diffuse infiltration of the anterior chamber and ciliary body by a filamentous mold.

Original languageEnglish (US)
Pages (from-to)1573-1577
Number of pages5
JournalClinical Ophthalmology
Issue number1
StatePublished - Sep 24 2012


  • Amphotericin B
  • Enucleation
  • Mold
  • Voriconazole

ASJC Scopus subject areas

  • Ophthalmology


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