Histone-modifying enzymes: Their role in the pathogenesis of acute leukemia and their therapeutic potential

Ly P. Vu, Luisa Luciani, Stephen D. Nimer

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Histone-modifying enzymes have recently been shown to play a central role in the regulation of both normal and malignant hematopoiesis. Post-translational modifications of histones and non-histone proteins underlies a regulatory complexity affecting numerous processes including transcriptional regulation, RNA processing and DNA damage response. Insights into the functions of these enzymes as well as their role in the epigenetic alterations found in leukemia will guide the development of novel therapeutic approaches. This review discusses examples of the proteins that have been implicated in the pathogenesis of leukemia, that may serve as potential therapeutic targets.

Original languageEnglish (US)
Pages (from-to)198-209
Number of pages12
JournalInternational journal of hematology
Volume97
Issue number2
DOIs
StatePublished - Feb 2013

Keywords

  • HATS
  • HDACs
  • Hematopoiesis
  • Histone-modifying enzymes
  • Leukemia
  • PKMTs
  • Post-translational modifications
  • PRMTs

ASJC Scopus subject areas

  • Hematology

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