Histone deacetylases (HDACs) and brain function

Claude Henry Volmar, Claes R Wahlestedt

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Modulation of gene expression is a constant and necessary event for mammalian brain function. An important way of regulating gene expression is through the remodeling of chromatin, the complex of DNA, and histone proteins around which DNA wraps. The "histone code hypothesis" places histone post-translational modifications as a significant part of chromatin remodeling to regulate transcriptional activity. Acetylation of histones by histone acetyl transferases and deacetylation by histone deacetylases (HDACs) at lysine residues are the most studied histone post-translational modifications in cognition and neuropsychiatric diseases. Here, we review the literature regarding the role of HDACs in brain function. Among the roles of HDACs in the brain, studies show that they participate in glial lineage development, learning and memory, neuropsychiatric diseases, and even rare neurologic diseases. Most HDACs can be targeted with small molecules. However, additional brain-penetrant specific inhibitors with high central nervous system exposure are needed to determine the cause-and-effect relationship between individual HDACs and brain-associated diseases.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalNeuroepigenetics
Volume1
DOIs
StatePublished - 2015

Fingerprint

Histone Deacetylases
Histones
Brain
Chromatin Assembly and Disassembly
Post Translational Protein Processing
Gene expression
Histone Code
Chromatin
Gene Expression
DNA
Brain Diseases
Acetylation
Transferases
Rare Diseases
Nervous System Diseases
Neuroglia
Cognition
Lysine
Neurology
Central Nervous System

Keywords

  • Brain function
  • Epigenetics
  • HAT
  • HDAC
  • Histone
  • Neuroepigenetics

ASJC Scopus subject areas

  • Biochemistry
  • Biological Psychiatry
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Developmental Neuroscience

Cite this

Histone deacetylases (HDACs) and brain function. / Volmar, Claude Henry; Wahlestedt, Claes R.

In: Neuroepigenetics, Vol. 1, 2015, p. 20-27.

Research output: Contribution to journalArticle

Volmar, Claude Henry ; Wahlestedt, Claes R. / Histone deacetylases (HDACs) and brain function. In: Neuroepigenetics. 2015 ; Vol. 1. pp. 20-27.
@article{ce6a2780a38f4e8aaab8e527a2bf81bb,
title = "Histone deacetylases (HDACs) and brain function",
abstract = "Modulation of gene expression is a constant and necessary event for mammalian brain function. An important way of regulating gene expression is through the remodeling of chromatin, the complex of DNA, and histone proteins around which DNA wraps. The {"}histone code hypothesis{"} places histone post-translational modifications as a significant part of chromatin remodeling to regulate transcriptional activity. Acetylation of histones by histone acetyl transferases and deacetylation by histone deacetylases (HDACs) at lysine residues are the most studied histone post-translational modifications in cognition and neuropsychiatric diseases. Here, we review the literature regarding the role of HDACs in brain function. Among the roles of HDACs in the brain, studies show that they participate in glial lineage development, learning and memory, neuropsychiatric diseases, and even rare neurologic diseases. Most HDACs can be targeted with small molecules. However, additional brain-penetrant specific inhibitors with high central nervous system exposure are needed to determine the cause-and-effect relationship between individual HDACs and brain-associated diseases.",
keywords = "Brain function, Epigenetics, HAT, HDAC, Histone, Neuroepigenetics",
author = "Volmar, {Claude Henry} and Wahlestedt, {Claes R}",
year = "2015",
doi = "1016/j.nepig.2014.10.002",
language = "English",
volume = "1",
pages = "20--27",
journal = "Neuroepigenetics",
issn = "2214-7845",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Histone deacetylases (HDACs) and brain function

AU - Volmar, Claude Henry

AU - Wahlestedt, Claes R

PY - 2015

Y1 - 2015

N2 - Modulation of gene expression is a constant and necessary event for mammalian brain function. An important way of regulating gene expression is through the remodeling of chromatin, the complex of DNA, and histone proteins around which DNA wraps. The "histone code hypothesis" places histone post-translational modifications as a significant part of chromatin remodeling to regulate transcriptional activity. Acetylation of histones by histone acetyl transferases and deacetylation by histone deacetylases (HDACs) at lysine residues are the most studied histone post-translational modifications in cognition and neuropsychiatric diseases. Here, we review the literature regarding the role of HDACs in brain function. Among the roles of HDACs in the brain, studies show that they participate in glial lineage development, learning and memory, neuropsychiatric diseases, and even rare neurologic diseases. Most HDACs can be targeted with small molecules. However, additional brain-penetrant specific inhibitors with high central nervous system exposure are needed to determine the cause-and-effect relationship between individual HDACs and brain-associated diseases.

AB - Modulation of gene expression is a constant and necessary event for mammalian brain function. An important way of regulating gene expression is through the remodeling of chromatin, the complex of DNA, and histone proteins around which DNA wraps. The "histone code hypothesis" places histone post-translational modifications as a significant part of chromatin remodeling to regulate transcriptional activity. Acetylation of histones by histone acetyl transferases and deacetylation by histone deacetylases (HDACs) at lysine residues are the most studied histone post-translational modifications in cognition and neuropsychiatric diseases. Here, we review the literature regarding the role of HDACs in brain function. Among the roles of HDACs in the brain, studies show that they participate in glial lineage development, learning and memory, neuropsychiatric diseases, and even rare neurologic diseases. Most HDACs can be targeted with small molecules. However, additional brain-penetrant specific inhibitors with high central nervous system exposure are needed to determine the cause-and-effect relationship between individual HDACs and brain-associated diseases.

KW - Brain function

KW - Epigenetics

KW - HAT

KW - HDAC

KW - Histone

KW - Neuroepigenetics

UR - http://www.scopus.com/inward/record.url?scp=84922739209&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84922739209&partnerID=8YFLogxK

U2 - 1016/j.nepig.2014.10.002

DO - 1016/j.nepig.2014.10.002

M3 - Article

AN - SCOPUS:84922739209

VL - 1

SP - 20

EP - 27

JO - Neuroepigenetics

JF - Neuroepigenetics

SN - 2214-7845

ER -