Histomorphometric Analysis of Postnatal Glomerulogenesis in Extremely Preterm Infants

Maria Rodriguez, Alexander H. Gómez, Carolyn Abitbol, Jayanthi Chandar, Shahnaz Duara, Gaston E Zilleruelo

Research output: Contribution to journalArticle

282 Citations (Scopus)

Abstract

Until now oligonephropathy to indicate "too few nephrons" has been associated with intrauterine growth restriction and experimentally induced abnormalities of renal development. The purpose of this study was to determine whether there is evidence of abnormal post-natal glomerulogenesis in extremely low birth weight preterm infants. Renal autopsy tissue was studied by computer-assisted morphometry from 56 extremely pre-mature infants (birth weight ≤ 1000 g) and 10 fullterm infants as controls. Preterm infants were divided into two groups (short survival < 40 days vs. long survival ≥40 days). Each group was subdivided into those with renal failure (RF) and those with normal renal function. Forty-two of 56 preterm infants (75%) were adequate for gestational age. Glomerulogenesis as measured by radial glomerular counts (RGC) was markedly decreased in all preterm infants as compared to term controls and correlated significantly with gestational age (r = 0.87; P < 0.001). Active glomerulogenesis with "basophilic S-shaped bodies" was absent in longer surviving preterm and all term infants. RGC of preterm infants surviving ≥40 days with RF were significantly less than RGC of those with long survival and no RF (P < 0.001). Only this latter group demonstrated increased glomerular size as measured by mesangial tuft area and Bowman's capsule area compared to all other groups (P < 0.001). The kidney continues to form postnatally in preterm neonates, but glomerulogenesis ceases after 40 days. Moreover, it is further inhibited by RF. Compensatory mechanisms in longer surviving preterm infants include glomerular hypertrophy and mesangial proliferation that could lead to hyperfiltration.

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalPediatric and Developmental Pathology
Volume7
Issue number1
StatePublished - Jan 1 2004

Fingerprint

Extremely Premature Infants
Premature Infants
Renal Insufficiency
Kidney
Gestational Age
Bowman Capsule
Extremely Low Birth Weight Infant
Nephrons
Birth Weight
Hypertrophy
Autopsy
Newborn Infant
Growth

Keywords

  • Computer assisted morphometry
  • Glomerulogenesis
  • Intrauterine growth restriction
  • Premature nephropathy
  • Prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Histomorphometric Analysis of Postnatal Glomerulogenesis in Extremely Preterm Infants. / Rodriguez, Maria; Gómez, Alexander H.; Abitbol, Carolyn; Chandar, Jayanthi; Duara, Shahnaz; Zilleruelo, Gaston E.

In: Pediatric and Developmental Pathology, Vol. 7, No. 1, 01.01.2004, p. 17-25.

Research output: Contribution to journalArticle

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