Histologic types of epithelial ovarian cancer: Have they different risk factors?

Allison W. Kurian, Raymond Balise, Valerie McGuire, Alice S. Whittemore

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

The histologic types of epithelial ovarian cancer differ in clinical behavior, descriptive epidemiology, and genetic origins. The goals of the current study were to characterize further the relation of histologic-specific ovarian cancer risks to reproductive and lifestyle attributes. The authors conducted a pooled analysis of 10 case-control studies of ovarian cancer in US White women, involving 1834 patients with invasive epithelial ovarian cancer (1067 serous, 254 mucinous, 373 endometrioid, and 140 clear cell) and 7484 control women. Risks of all four histological types were inversely associated with parity and oral contraceptive use, but the histologic types showed different associations with nonreproductive factors. Unique associations include an inverse relation of serous cancer risk to body mass index, a positive relation of mucinous cancer risk to cigarette smoking, and a weakly positive relation of endometrioid cancer risk to body mass index. Risk of all histologic types was unassociated with age at menarche, age at menopause, a history of infertility, noncontraceptive estrogen use, and alcohol consumption. The most important modifiers of ovarian cancer risk (parity and oral contraceptive use) showed similar associations across the histologies. Nevertheless, the unique associations seen for other modifiers support the conjecture that the histologic types of epithelial ovarian cancer have different etiologies, which should be addressed in future investigations of the molecular basis of ovarian cancers and their responses to therapies.

Original languageEnglish (US)
Pages (from-to)520-530
Number of pages11
JournalGynecologic Oncology
Volume96
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Ovarian Neoplasms
Oral Contraceptives
Parity
Body Mass Index
Neoplasms
Menarche
Molecular Epidemiology
Menopause
Ovarian epithelial cancer
Alcohol Drinking
Infertility
Case-Control Studies
Life Style
Histology
Estrogens
Smoking
Therapeutics

Keywords

  • Case-control study
  • Clear cell
  • Endometrioid
  • Histology
  • Mucinous
  • Ovarian cancer
  • Risk factors
  • Serous

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Oncology

Cite this

Histologic types of epithelial ovarian cancer : Have they different risk factors? / Kurian, Allison W.; Balise, Raymond; McGuire, Valerie; Whittemore, Alice S.

In: Gynecologic Oncology, Vol. 96, No. 2, 02.2005, p. 520-530.

Research output: Contribution to journalArticle

Kurian, Allison W. ; Balise, Raymond ; McGuire, Valerie ; Whittemore, Alice S. / Histologic types of epithelial ovarian cancer : Have they different risk factors?. In: Gynecologic Oncology. 2005 ; Vol. 96, No. 2. pp. 520-530.
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