Histologic changes following continuous wave and micropulse transscleral cyclophotocoagulation: A randomized comparative study

Kareem Moussa, Max Feinstein, Melike Pekmezci, Jun Hui Lee, Michele Bloomer, Catherine Oldenburg, Zhimin Sun, Richard K. Lee, Gui Shuang Ying, Ying Han

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: To compare the macroscopic and microscopic histologic changes in eyes treated with micropulse transscleral cyclophotocoagulation (MP-TCP) versus continuous wave transscleral cyclophotocoagulation (CW-TCP). Methods: Twelve halves of globes from three pairs of adult cadaveric eyes were randomly assigned to nontreated control, CW-TCP, single MP-TCP treatment, or double MP-TCP treatments, and then sectioned for histologic analysis. Presence or absence of the following four unique histologic changes was recorded: splitting within the ciliary process epithelium (splitting), separation of the pigmented ciliary process epithelium from the stroma (separation), coagulation of collagen and destruction of ciliary process stroma (coagulation), and full-thickness destruction of ciliary process epithelium (destruction). Results: A total of 498 slides were analyzed, and laser scars in all treated specimens were located in the pars plana. Logistic regression analysis showed that compared with controls, CW-TCP-treated specimens were significantly more likely to experience separation (odds ratio [OR] = 11.1, P = 0.02), coagulation (OR = 24.3, P = 0.002), and destruction (OR = 11.1, P = 0.03). Destruction of the ciliary process epithelium was observed exclusively in CW-TCP-treated sections. No significant differences in histologic features were observed between controls and MP-TCP. Conclusions: MP-TCP does not produce significant histologic changes in cadaveric eyes, whereas CW-TCP treatment does. Translational Relevance: These findings improve understanding of the mechanism of MP-TCP, help explain the increased rates of adverse effects following CW-TCP treatment compared with MP-TCP, and describe effects of MP-TCP at various doses.

Original languageEnglish (US)
Article number22
Pages (from-to)1-9
Number of pages9
JournalTranslational Vision Science and Technology
Issue number5
StatePublished - 2020


  • CW-TCP
  • Cyclophotocoagulation
  • Histology
  • MP-TCP

ASJC Scopus subject areas

  • Biomedical Engineering
  • Ophthalmology


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