Histocompatibility antigens (HLA) and patterns of cognitive loss in dementia of the Alzheimer type

Donna Cohen, Carl Eisdorfer, Roy L. Walford

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Recent data suggest that a proportion of patients with primary neuronal degeneration of the Alzheimer type have the HLA-B7 antigen. However, the possibility that other differences might exist between patients with and without the marker has not been examined. We tested a range of cognitive skills in Alzheimer patients with and without the HLA-B7 to examine whether those individuals with the HLA marker would exhibit a profile of cognitive loss different from those without it. Our results indicate that patients with HLA-B7 antigens had selective attentional scores that were significantly lower than Alzheimer patients without the antigen. Neither group was significantly different in either memory capacity or retrieval from short-term and long-term memory. The data support the hypothesis that there may be more than one disorder in what is now referred to as dementia of the Alzheimer type.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalNeurobiology of aging
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1981

Keywords

  • Alzheimer's disease
  • Cognitive loss
  • Dementia
  • HLA antigens

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

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