Histocompatibility antigens (HLA) and patterns of cognitive loss in dementia of the Alzheimer type

Donna Cohen, Carl Eisdorfer, Roy L. Walford

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Recent data suggest that a proportion of patients with primary neuronal degeneration of the Alzheimer type have the HLA-B7 antigen. However, the possibility that other differences might exist between patients with and without the marker has not been examined. We tested a range of cognitive skills in Alzheimer patients with and without the HLA-B7 to examine whether those individuals with the HLA marker would exhibit a profile of cognitive loss different from those without it. Our results indicate that patients with HLA-B7 antigens had selective attentional scores that were significantly lower than Alzheimer patients without the antigen. Neither group was significantly different in either memory capacity or retrieval from short-term and long-term memory. The data support the hypothesis that there may be more than one disorder in what is now referred to as dementia of the Alzheimer type.

Original languageEnglish
Pages (from-to)277-280
Number of pages4
JournalNeurobiology of Aging
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Histocompatibility Antigens
Alzheimer Disease
B7 Antigens
Long-Term Memory
Antigens

Keywords

  • Alzheimer's disease
  • Cognitive loss
  • Dementia
  • HLA antigens

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Histocompatibility antigens (HLA) and patterns of cognitive loss in dementia of the Alzheimer type. / Cohen, Donna; Eisdorfer, Carl; Walford, Roy L.

In: Neurobiology of Aging, Vol. 2, No. 4, 01.01.1981, p. 277-280.

Research output: Contribution to journalArticle

Cohen, Donna ; Eisdorfer, Carl ; Walford, Roy L. / Histocompatibility antigens (HLA) and patterns of cognitive loss in dementia of the Alzheimer type. In: Neurobiology of Aging. 1981 ; Vol. 2, No. 4. pp. 277-280.
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