Histochemical studies in experimental portal systemic encephalopathy. I. Glutamic dehydrogenase

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33 Citations (Scopus)

Abstract

Results of a histochemical study of glutamic dehydrogenase in experimental portal systemic encephalopathy with hyperammonemia indicate that the enzyme's activity in brain was increased in all stages of the encephalopathy, and this increase appeared to be localized exclusively in astrocytes. The results are consistent with the view that the astrocyte has a critical role in ammonia metabolism in brain, probably in ammonia detoxification. The findings, moreover, indicate that one pool of glutamate, possibly the small pool, is located in the astrocyte.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalArchives of Neurology
Volume33
Issue number4
StatePublished - Dec 1 1976
Externally publishedYes

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Hepatic Encephalopathy
Astrocytes
Oxidoreductases
Ammonia
Hyperammonemia
Brain
Brain Diseases
Glutamic Acid
Enzymes
Metabolism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Histochemical studies in experimental portal systemic encephalopathy. I. Glutamic dehydrogenase. / Norenberg, Michael D.

In: Archives of Neurology, Vol. 33, No. 4, 01.12.1976, p. 265-269.

Research output: Contribution to journalArticle

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