Histochemical Studies in Experimental Portal-Systemic Encephalopathy: I. Glutamic Dehydrogenase

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33 Scopus citations


Results of a histochemical study of glutamic dehydrogenase in experimental portal systemic encephalopathy with hyperammonemia indicate that the enzyme's activity in brain was increased in all stages of the encephalopathy, and this increase appeared to be localized exclusively in astrocytes. The results are consistent with the view that the astrocyte has a critical role in ammonia metabolism in brain, probably in ammonia detoxification. The findings, moreover, indicate that one pool of glutamate, possibly the small pool, is located in the astrocyte.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalArchives of neurology
Issue number4
StatePublished - Apr 1976
Externally publishedYes

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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