Hispanic Americans and Non-Hispanic White Americans Have a Similar Inflammatory Bowel Disease Phenotype: A Systematic Review with Meta-Analysis

Danny J. Avalos, Antonio Mendoza-Ladd, Marc J. Zuckerman, Mohammad Bashashati, Andres Alvarado, Alok Dwivedi, Oriana M. Damas

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background: Inflammatory bowel disease (IBD) is a devastating immune-mediated disease on the rise in Hispanics living in the USA. Prior observational studies comparing IBD characteristics between Hispanics and non-Hispanic whites (NHW) have yielded mixed results. Aims: We performed a meta-analysis of observational studies examining IBD phenotype in Hispanics compared to NHW. Methods: We conducted a systematic search of US-based studies comparing IBD subtype (Ulcerative Colitis: UC or Crohn’s disease: CD) and phenotype (disease location and behavior) between Hispanics and NHW. We evaluated differences in age at IBD diagnosis, the presence of family history and smoking history. A random effects model was chosen “a priori.” Categorical and continuous variables were analyzed using odds ratio (OR) or standard mean difference (SMD), respectively. Results: Seven studies were included with 687 Hispanics and 1586 NHW. UC was more common in Hispanics compared to NHW (OR 2.07, CI 1.13–3.79, p = 0.02). Location of disease was similar between Hispanics and NHW except for the presence of upper gastrointestinal CD, which was less common in Hispanics (OR 0.58, CI 0.32–1.06, p = 0.07). Hispanics were less likely to smoke (OR 0.48, CI 0.26–0.89, p = 0.02) or have a family history of IBD (OR 0.35, CI 0.22–0.55, p < 0.001). CD behavior classified by Montreal classification and age at IBD diagnosis were similar between Hispanics and NHW. Conclusion: UC was more common among US Hispanics compared to NHW. Age at IBD diagnosis is similar for both Hispanics and NHW. For CD, disease behavior is similar, but Hispanics show a trend for less upper gastrointestinal involvement. A family history of IBD and smoking history were less common in Hispanics.

Original languageEnglish (US)
Pages (from-to)1558-1571
Number of pages14
JournalDigestive Diseases and Sciences
Issue number6
StatePublished - Jun 1 2018


  • Hispanic Americans
  • Inflammatory bowel diseases
  • Minority groups
  • Phenotype

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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