Highly enantioselective synthesis of a fluorescent amino acid

Péter Kele, Guodong Sui, Qun Huo, Roger M. Leblanc

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

A high enantiomeric excess (gt;99.5%) synthesis of L-2-amino-3-(7-methoxy-4-coumaryl) propionic acid (L-Amp) is described. The two step synthesis route of this non-proteinogenic amino acid includes an oxazinone derivative as glycine enolate, which is alkylated with the fluorogenic group.

Original languageEnglish (US)
Pages (from-to)4959-4963
Number of pages5
JournalTetrahedron Asymmetry
Volume11
Issue number24
DOIs
StatePublished - Dec 15 2000

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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