Highly enantioselective synthesis of a fluorescent amino acid

Péter Kele, Guodong Sui, Qun Huo, Roger Leblanc

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A high enantiomeric excess (gt;99.5%) synthesis of L-2-amino-3-(7-methoxy-4-coumaryl) propionic acid (L-Amp) is described. The two step synthesis route of this non-proteinogenic amino acid includes an oxazinone derivative as glycine enolate, which is alkylated with the fluorogenic group.

Original languageEnglish
Pages (from-to)4959-4963
Number of pages5
JournalTetrahedron Asymmetry
Volume11
Issue number24
DOIs
StatePublished - Dec 15 2000

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Glycine
amino acids
Amino acids
Amino Acids
propionic acid
Propionic acid
synthesis
glycine
routes
Derivatives
2-amino-3-(7-methoxy-4-coumaryl)propionic acid

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Highly enantioselective synthesis of a fluorescent amino acid. / Kele, Péter; Sui, Guodong; Huo, Qun; Leblanc, Roger.

In: Tetrahedron Asymmetry, Vol. 11, No. 24, 15.12.2000, p. 4959-4963.

Research output: Contribution to journalArticle

Kele, Péter ; Sui, Guodong ; Huo, Qun ; Leblanc, Roger. / Highly enantioselective synthesis of a fluorescent amino acid. In: Tetrahedron Asymmetry. 2000 ; Vol. 11, No. 24. pp. 4959-4963.
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