Abstract
Aryl pyrimidones are pharmacologically relevant compounds whose optical properties have only been partially explored. We report the synthesis and optical characterization of a series of aryl- and diaryl-2(1H)-pyrimidones. The electronic transitions of these chromophores are modulated by the extent of conjugation between the pendant phenyl ring and the pyrimidone core as well as the presence of electron-donating auxochromes. Monoprotonation of the pyrimidone ring results in large hyperchromic and bathochromic shifts as well as switching of fluorescence making these phenyl pyrimidones of interest as sensory materials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4188-4191 |
| Number of pages | 4 |
| Journal | Organic letters |
| Volume | 13 |
| Issue number | 16 |
| DOIs | |
| State | Published - Aug 19 2011 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Dhuguru, J., Gheewala, C., Kumar, N. S. S., & Wilson, J. N. (2011). Highly chromic, proton-responsive phenyl pyrimidones. Organic letters, 13(16), 4188-4191. https://doi.org/10.1021/ol2014945