Higher grade transformation of follicular lymphoma: Phenotypic tumor progression associated with diverse genetic lesions

Izidore S. Lossos; Ronald Levy

doi:10.1016/S1044-579X(03)00015-4

Higher grade transformation of follicular lymphoma: Phenotypic tumor progression associated with diverse genetic lesions

Izidore S. Lossos, Ronald Levy

Medicine

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads to clinically and phenotypically similar end-point can occur by functionally diverse genetic lesions. The most commonly identified genetic alterations associated with the FCL transformation are TP53 gene mutations, inactivation of CDKN2A and CDKN2B genes and deregulation of the C-MYC gene. These lesions affect different aspects of normal cell physiology (apoptosis, cell cycle control, and proliferation) and are potential targets for gene-specific therapies.

Original language	English (US)
Pages (from-to)	191-202
Number of pages	12
Journal	Seminars in Cancer Biology
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/S1044-579X(03)00015-4
State	Published - Jun 2003

Keywords

C-MYC
Diffuse large B-cell lymphoma
Follicle center lymphoma
Molecular changes
Transformation

ASJC Scopus subject areas

Cancer Research

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title = "Higher grade transformation of follicular lymphoma: Phenotypic tumor progression associated with diverse genetic lesions",

abstract = "Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads to clinically and phenotypically similar end-point can occur by functionally diverse genetic lesions. The most commonly identified genetic alterations associated with the FCL transformation are TP53 gene mutations, inactivation of CDKN2A and CDKN2B genes and deregulation of the C-MYC gene. These lesions affect different aspects of normal cell physiology (apoptosis, cell cycle control, and proliferation) and are potential targets for gene-specific therapies.",

keywords = "C-MYC, Diffuse large B-cell lymphoma, Follicle center lymphoma, Molecular changes, Transformation",

author = "Lossos, {Izidore S.} and Ronald Levy",

note = "Funding Information: Some of the data summarized in this paper is the result of collaborative work with researchers at the Stanford University; Hospital Cl{\'ı}nico, University of Valencia, Spain; and University of California, San Francisco. Key individuals who contributed to these studies are Ash A. Alizadeh, Maximilian Diehn, Roger Warnke, Yvonne Thorstenson, Peter J. Oefner, Patrick O. Brown, David Botstein Jose, A. Martinez-Climent, and Daniel Pinkel. Supported by Grants CA33399 and CA34233 from the USPHS-NIH. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2003",

month = jun,

doi = "10.1016/S1044-579X(03)00015-4",

language = "English (US)",

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T2 - Phenotypic tumor progression associated with diverse genetic lesions

AU - Lossos, Izidore S.

AU - Levy, Ronald

N1 - Funding Information: Some of the data summarized in this paper is the result of collaborative work with researchers at the Stanford University; Hospital Clı́nico, University of Valencia, Spain; and University of California, San Francisco. Key individuals who contributed to these studies are Ash A. Alizadeh, Maximilian Diehn, Roger Warnke, Yvonne Thorstenson, Peter J. Oefner, Patrick O. Brown, David Botstein Jose, A. Martinez-Climent, and Daniel Pinkel. Supported by Grants CA33399 and CA34233 from the USPHS-NIH. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2003/6

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N2 - Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads to clinically and phenotypically similar end-point can occur by functionally diverse genetic lesions. The most commonly identified genetic alterations associated with the FCL transformation are TP53 gene mutations, inactivation of CDKN2A and CDKN2B genes and deregulation of the C-MYC gene. These lesions affect different aspects of normal cell physiology (apoptosis, cell cycle control, and proliferation) and are potential targets for gene-specific therapies.

AB - Higher grade histological transformation of follicular lymphoma (FL) to more aggressive diffuse large B-cell lymphomas (DLBCL) occurs in 10-60% of the cases. Review of the current knowledge of genetic and molecular alterations associated with the higher grade transformation of FCL suggests that the process that leads to clinically and phenotypically similar end-point can occur by functionally diverse genetic lesions. The most commonly identified genetic alterations associated with the FCL transformation are TP53 gene mutations, inactivation of CDKN2A and CDKN2B genes and deregulation of the C-MYC gene. These lesions affect different aspects of normal cell physiology (apoptosis, cell cycle control, and proliferation) and are potential targets for gene-specific therapies.

KW - C-MYC

KW - Diffuse large B-cell lymphoma

KW - Follicle center lymphoma

KW - Molecular changes

KW - Transformation

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Higher grade transformation of follicular lymphoma: Phenotypic tumor progression associated with diverse genetic lesions

Abstract

Keywords

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