High-throughput cell manipulation using ultrasound fields

Deok Ho Kim, Albrecht Haake, Yu Sun, Adrian P. Neild, Jong Eun Ihm, Jürg Dual, Jeffrey A. Hubbell, Byeong Kwon Ju, Bradley J. Nelson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

13 Citations (Scopus)

Abstract

This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages2571-2574
Number of pages4
Volume26 IV
StatePublished - 2004
Externally publishedYes
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

Fingerprint

Ultrasonics
Throughput
Lab-on-a-chip
Stem cells
Acoustics
Cells
Liquids

Keywords

  • Cell manipulation
  • Cell sorting
  • High-throughput
  • Ultrasound field
  • Viability

ASJC Scopus subject areas

  • Bioengineering

Cite this

Kim, D. H., Haake, A., Sun, Y., Neild, A. P., Ihm, J. E., Dual, J., ... Nelson, B. J. (2004). High-throughput cell manipulation using ultrasound fields. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (Vol. 26 IV, pp. 2571-2574)

High-throughput cell manipulation using ultrasound fields. / Kim, Deok Ho; Haake, Albrecht; Sun, Yu; Neild, Adrian P.; Ihm, Jong Eun; Dual, Jürg; Hubbell, Jeffrey A.; Ju, Byeong Kwon; Nelson, Bradley J.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 IV 2004. p. 2571-2574.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kim, DH, Haake, A, Sun, Y, Neild, AP, Ihm, JE, Dual, J, Hubbell, JA, Ju, BK & Nelson, BJ 2004, High-throughput cell manipulation using ultrasound fields. in Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 26 IV, pp. 2571-2574, Conference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004, San Francisco, CA, United States, 9/1/04.
Kim DH, Haake A, Sun Y, Neild AP, Ihm JE, Dual J et al. High-throughput cell manipulation using ultrasound fields. In Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 IV. 2004. p. 2571-2574
Kim, Deok Ho ; Haake, Albrecht ; Sun, Yu ; Neild, Adrian P. ; Ihm, Jong Eun ; Dual, Jürg ; Hubbell, Jeffrey A. ; Ju, Byeong Kwon ; Nelson, Bradley J. / High-throughput cell manipulation using ultrasound fields. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. Vol. 26 IV 2004. pp. 2571-2574
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