High-throughput cell manipulation using ultrasound fields

Deok Ho Kim, Albrecht Haake, Yu Sun, Adrian P. Neild, Jong Eun Ihm, Jürg Dual, Jeffrey A. Hubbell, Byeong Kwon Ju, Bradley J. Nelson

Research output: Contribution to journalConference article

Abstract

This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.

Original languageEnglish (US)
Pages (from-to)2571-2574
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume26 IV
StatePublished - Dec 1 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

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Keywords

  • Cell manipulation
  • Cell sorting
  • High-throughput
  • Ultrasound field
  • Viability

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Kim, D. H., Haake, A., Sun, Y., Neild, A. P., Ihm, J. E., Dual, J., Hubbell, J. A., Ju, B. K., & Nelson, B. J. (2004). High-throughput cell manipulation using ultrasound fields. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 26 IV, 2571-2574.