High risk of HIV-related mortality is associated with selenium deficiency

Marianna K. Baum, Gail Shor-Posner, Shenghan Lai, Guoyan Zhang, Hong Lai, Mary Ann Fletcher, Howerde Sauberlich, John Page

Research output: Contribution to journalArticle

313 Citations (Scopus)

Abstract

To determine the independent contribution of specific immunologic and nutritional factors on survival in HIV-1 disease, CD4 cell count, antiretroviral treatment, plasma levels of vitamins A, E, B6, and B12 and minerals selenium and zinc were considered in relation to relative risk for HIV-related mortality. Immune parameters and nutrients known to affect immune function were evaluated at 6-month intervals in 125 HIV-1-seropositive drug- using men and women in Miami, FL, over 3.5 years. A total of 21 of the HIV- 1-infected participants died of HIV-related causes during the 3.5-year longitudinal study. Subclinical malnutrition (i.e., overly low levels of prealbumin, relative risk [RR] = 4.01, p < 0.007), deficiency of vitamin A (RR = 3.23, p < 0.03), vitamin B12 deficiency (RR = 8.33,p < 0.009), zinc deficiency (RR = 2.29.1, p < 0.04), and selenium deficiency (RR = 19.9, p < 0.0001) over time, but not zidovudine treatment, were shown to each be associated with HIV-1-related mortality independent of CD4 cell counts <200/mm3 at baseline, and CD4 counts over time. When all factors that could affect survival, including CD4 counts <200/mm3 at baseline, CD4 levels over time, and nutrient deficiencies were considered jointly, only CD4 counts over time (RR = 0.69, p < 0.04) and selenium deficiency (RR = 10.8, p <0.002) were significantly associated with mortality. These results indicate that selenium deficiency is an independent predictor of survival for those with HIV-1 infection.

Original languageEnglish
Pages (from-to)370-374
Number of pages5
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume15
Issue number5
StatePublished - Aug 15 1997

Fingerprint

Selenium
HIV
CD4 Lymphocyte Count
Mortality
HIV-1
Survival
Zinc
Vitamin B 12 Deficiency
Vitamin A Deficiency
Food
Prealbumin
Zidovudine
Immunologic Factors
Vitamin A
Vitamin E
Malnutrition
HIV Infections
Minerals
Longitudinal Studies
Therapeutics

Keywords

  • HIV infection
  • Mortality
  • Nutrition
  • Selenium

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

Cite this

High risk of HIV-related mortality is associated with selenium deficiency. / Baum, Marianna K.; Shor-Posner, Gail; Lai, Shenghan; Zhang, Guoyan; Lai, Hong; Fletcher, Mary Ann; Sauberlich, Howerde; Page, John.

In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, Vol. 15, No. 5, 15.08.1997, p. 370-374.

Research output: Contribution to journalArticle

Baum, MK, Shor-Posner, G, Lai, S, Zhang, G, Lai, H, Fletcher, MA, Sauberlich, H & Page, J 1997, 'High risk of HIV-related mortality is associated with selenium deficiency', Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, vol. 15, no. 5, pp. 370-374.
Baum MK, Shor-Posner G, Lai S, Zhang G, Lai H, Fletcher MA et al. High risk of HIV-related mortality is associated with selenium deficiency. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1997 Aug 15;15(5):370-374.
Baum, Marianna K. ; Shor-Posner, Gail ; Lai, Shenghan ; Zhang, Guoyan ; Lai, Hong ; Fletcher, Mary Ann ; Sauberlich, Howerde ; Page, John. / High risk of HIV-related mortality is associated with selenium deficiency. In: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 1997 ; Vol. 15, No. 5. pp. 370-374.
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