High-resolution optical coherence tomography findings of lisch epithelial corneal dystrophy

Cameron Pole, Adam Sise, Madhura Joag, Anat Galor, Jose A. Bermudez-Magner, Sander Dubovy, Carol L. Karp

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Purpose: To describe a case of Lisch epithelial corneal dystrophy (LECD) and present its unique characteristics on high-resolution optical coherence tomography (HR-OCT). Methods: A 78-year-old man with whorled corneal epithelial opacities in the right eye was referred for the evaluation of ocular surface squamous neoplasia. Clinical evaluation, photographs, and HR-OCT images of the cornea involved were obtained and scrapings of the affected cornea were sent for histopathologic analysis. Results: Clinically, the patient presented with an opalescent whirling epithelium in a linear pattern encroaching on the visual axis. HR-OCT showed normal thickness epithelial hyperreflectivity of involved cornea without stromal involvement, along with sharply demarcated borders of unaffected tissue. Histopathologic findings demonstrated vacuolated periodic acid-Schiff (PAS) positive cells throughout the epithelial layers consistent with LECD. Conclusions: HR-OCT was able to provide useful information to rule out ocular surface squamous neoplasia and confirm the clinical impression of LECD at the time of clinical examination. HR-OCT shows promise as an adjunctive diagnostic tool for ocular surface lesions and pathologies.

Original languageEnglish (US)
Pages (from-to)392-394
Number of pages3
Issue number3
StatePublished - 2016


  • Corneal dystrophy
  • Lisch epithelial corneal dystrophy
  • Oct
  • Optical coherence tomography

ASJC Scopus subject areas

  • Ophthalmology


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