High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy

Cameron Pole, Adam Sise, Madhura Joag, Anat Galor, Jose A. Bermudez-Magner, Sander Dubovy, Carol Karp

Research output: Contribution to journalArticle

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Abstract

PURPOSE:: To describe a case of Lisch epithelial corneal dystrophy (LECD) and present its unique characteristics on high-resolution optical coherence tomography (HR-OCT). METHODS:: A 78-year-old man with whorled corneal epithelial opacities in the right eye was referred for the evaluation of ocular surface squamous neoplasia. Clinical evaluation, photographs, and HR-OCT images of the cornea involved were obtained and scrapings of the affected cornea were sent for histopathologic analysis. RESULTS:: Clinically, the patient presented with an opalescent whirling epithelium in a linear pattern encroaching on the visual axis. HR-OCT showed normal thickness epithelial hyperreflectivity of involved cornea without stromal involvement, along with sharply demarcated borders of unaffected tissue. Histopathologic findings demonstrated vacuolated periodic acid-Schiff (PAS) positive cells throughout the epithelial layers consistent with LECD. CONCLUSIONS:: HR-OCT was able to provide useful information to rule out ocular surface squamous neoplasia and confirm the clinical impression of LECD at the time of clinical examination. HR-OCT shows promise as an adjunctive diagnostic tool for ocular surface lesions and pathologies.

Original languageEnglish (US)
JournalCornea
DOIs
StateAccepted/In press - Jan 13 2016

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Optical Coherence Tomography
Cornea
Corneal Opacity
Periodic Acid
Neoplasms
Epithelium
Epithelial Cells
Lisch Epithelial Corneal Dystrophy
Pathology

ASJC Scopus subject areas

  • Ophthalmology

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High-Resolution Optical Coherence Tomography Findings of Lisch Epithelial Corneal Dystrophy. / Pole, Cameron; Sise, Adam; Joag, Madhura; Galor, Anat; Bermudez-Magner, Jose A.; Dubovy, Sander; Karp, Carol.

In: Cornea, 13.01.2016.

Research output: Contribution to journalArticle

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AU - Dubovy, Sander

AU - Karp, Carol

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