High quality, small molecule-activity datasets for kinase research [version 1; referees: 2 approved]

Rajan Sharma, Stephan C Schuerer, Steven M. Muskal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Kinases regulate cell growth, movement, and death. Deregulated kinase activity is a frequent cause of disease. The therapeutic potential of kinase inhibitors has led to large amounts of published structure activity relationship (SAR) data. Bioactivity databases such as the Kinase Knowledgebase (KKB), WOMBAT, GOSTAR, and ChEMBL provide researchers with quantitative data characterizing the activity of compounds across many biological assays. The KKB, for example, contains over 1.8M kinase structure-activity data points reported in peer-reviewed journals and patents. In the spirit of fostering methods development and validation worldwide, we have extracted and have made available from the KKB 258K structure activity data points and 76K associated unique chemical structures across eight kinase targets. These data are freely available for download within this data note.

Original languageEnglish (US)
Article number1366
JournalF1000Research
Volume5
DOIs
StatePublished - 2016

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Phosphotransferases
Molecules
Research
Knowledge Bases
Foster Home Care
Patents
Datasets
Cell growth
Structure-Activity Relationship
Bioactivity
Biological Assay
Cell Movement
Assays
Cell Death
Research Personnel
Databases
Growth

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

High quality, small molecule-activity datasets for kinase research [version 1; referees : 2 approved]. / Sharma, Rajan; Schuerer, Stephan C; Muskal, Steven M.

In: F1000Research, Vol. 5, 1366, 2016.

Research output: Contribution to journalArticle

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