High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial

Anneke C. Hesseling, S. Kim, S. Madhi, S. Nachman, H. S. Schaaf, A. Violari, T. C. Victor, G. McSherry, C. Mitchell, M. F. Cotton

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

An emergence of drug-resistant tuberculosis (DR-TB) in settings affected by human immunodeficiency virus (HIV) and tuberculosis (TB) has been observed. We investigated the prevalence of DR-TB in P1041, a multicentred, randomised, double-blind trial which compared the administration of isoniazid (INH) to placebo, in HIV-exposed, non-infected and -infected African infants in the absence of any documented TB exposure. The prevalence of multidrug-resistant TB (MDR-TB) was 22.2% (95%CI 8.5-45.8) and INH monoresistance 5.6% (95%CI 0.1-27.6) among culture-confirmed cases, with all MDR-TB occurring in a single site. There was no association between INH treatment or placebo group, or between HIV infection status, and DR-TB prevalence. There was a high prevalence of DR-TB among HIV-exposed and -infected children. Surveillance of DR-TB among children in high-burden TB-HIV settings should be routine.

Original languageEnglish (US)
Pages (from-to)192-195
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume16
Issue number2
DOIs
StatePublished - Feb 1 2012

Keywords

  • Children
  • HIV
  • Isoniazid prevention
  • Resistance
  • Tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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    Hesseling, A. C., Kim, S., Madhi, S., Nachman, S., Schaaf, H. S., Violari, A., Victor, T. C., McSherry, G., Mitchell, C., & Cotton, M. F. (2012). High prevalence of drug resistance amongst HIV-exposed and -infected children in a tuberculosis prevention trial. International Journal of Tuberculosis and Lung Disease, 16(2), 192-195. https://doi.org/10.5588/ijtld.10.0795