High molecular weight, but not total, CTRP3 levels are associated with serum triglyceride levels

Greta Trogen, Arsham Alamian, Jonathan M. Peterson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


C1q/TNF-related protein 3 (CTRP3) is a relatively novel adipose tissue-derived cytokine (adipokine) which has been linked to improved glucose regulation and insulin sensitivity. However, the relationship between circulating CTRP3 levels and diabetes is controversial. CTRP3 can circulate in different oligomeric complexes: trimeric, hexameric, and high molecular weight (HMW) oligomeric complexes. However, the concentration of the different oligomeric complexes in human disease states has not been previously investigated. Therefore, the purpose of this study was to compare the levels of different oligomeric complexes of CTRP3 between type 2 diabetic and nondiabetic individuals. Additionally, the association between the oligomeric complexes and other serum factors was examined. CTRP3 primarily circulates in the HMW complex (>50%) and the hexametric multimer, with no CTRP3 detected in the trimeric complex or as a monomer. Further, no differences were observed in total, hexameric, or HMW CTRP3 levels regardless of diabetic status. Surprisingly, HMW CTRP3 was found to be positively correlated with circulating triglyceride levels. Combined, these data suggest that CTRP3 is associated with triglyceride regulation, not diabetic status. These data may explain some of the discrepancies in the literature as elevated triglyceride levels are often detected in patients with obesity and type 2 diabetes.

Original languageEnglish (US)
Article numbere14306
JournalPhysiological Reports
Issue number23
StatePublished - Dec 1 2019
Externally publishedYes


  • adipokines
  • adiponectin
  • adipose tissue-derived cytokine
  • CTRP3

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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