TY - JOUR
T1 - High-dose intravenous gamma globulin to suppress alloimmune destruction of donor platelets
AU - Junghans, Richard P.
AU - Ahn, Yeon S.
N1 - Funding Information:
From the Center for Blood Diseases, University of Miami School of Medicine, and the Medical and Research Services, Miami Veterans Administration Hospital, Miami, Florida. This study was supported by National Institutes of Health Grant AM-25485, Veterans Administration Merit Review Award, Project Number 021501. and Mary Beth Weiss Research Fund, and gifls given by Kenneth Chasen. Requests for reprints should be addressed to Dr. R. P. Junghans, center for Blood Diseases (R-361,G eorgetown University Hospital, 3800 Reservoir Road, North West, Washington, DC. 20007.
PY - 1984/3/30
Y1 - 1984/3/30
N2 - We report the use of high-dose intravenous gamma globulin to overcome refractoriness to platelet transfusion in an alloimmunized patient with acute leukemia and thrombocytopenia. For two years the patient suffered recurrent gastrointestinal bleeding from an arteriovenous malformation and was given multiple transfusions, providing a basis for his allosensitization. Platelet counts had not increased following transfusions of random-donor or HLA-matched platelets. With intravenous gamma globulin, one hour after the transfusion of 9 to 15 units of platelets, the count increased by 30,000 to 90,000 and the half-life of transfused platelets increased to three to four hours from an estimated 0.05 hours prior to therapy. Intravenous gamma globulin arrested massive gastrointestinal bleeding and allowed the patient to undergo surgical resection of the small bowel with minimal operative blood loss.
AB - We report the use of high-dose intravenous gamma globulin to overcome refractoriness to platelet transfusion in an alloimmunized patient with acute leukemia and thrombocytopenia. For two years the patient suffered recurrent gastrointestinal bleeding from an arteriovenous malformation and was given multiple transfusions, providing a basis for his allosensitization. Platelet counts had not increased following transfusions of random-donor or HLA-matched platelets. With intravenous gamma globulin, one hour after the transfusion of 9 to 15 units of platelets, the count increased by 30,000 to 90,000 and the half-life of transfused platelets increased to three to four hours from an estimated 0.05 hours prior to therapy. Intravenous gamma globulin arrested massive gastrointestinal bleeding and allowed the patient to undergo surgical resection of the small bowel with minimal operative blood loss.
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U2 - 10.1016/0002-9343(84)90343-7
DO - 10.1016/0002-9343(84)90343-7
M3 - Article
C2 - 6424453
AN - SCOPUS:0021248873
VL - 76
SP - 204
EP - 208
JO - American Journal of Medicine
JF - American Journal of Medicine
SN - 0002-9343
IS - 3 PART 1
ER -