High-density lipoprotein subfractions and carotid plaque: The Northern Manhattan Study

Eduard Tiozzo, Hannah Gardener, Barry Hudson, Chuanhui Dong, David Della-Morte, Milita Crisby, Ronald B. Goldberg, Mitchell S.V. Elkind, Ying Kuen Cheung, Clinton B Wright, Ralph L. Sacco, Tatjana Rundek

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: The objective of this cross-sectional analysis was to investigate the relation between two major high-density lipoprotein cholesterol (HDL-C) subfractions (HDL2-C and HDL3-C) and carotid plaque in a population based cohort. Methods: We evaluated 988 stroke-free participants (mean age 66±8 years; 40% men; 66% Hispanic and 34% Non-Hispanic) with available data on HDL subfractions using precipitation method and carotid plaque area and thickness assessed by a high-resolution 2D ultrasound. The associations between HDL-C subfractions and plaque measurements were analyzed by quantile regression. Results: Plaque was present in 56% of the study population. Among those with plaque, the mean±SD plaque area was 19.40±20.46mm2 and thickness 2.30±4.45mm. The mean±SD total HDL-C was 46±14mg/dl, HDL2-C 14±8mg/dl, and HDL3-C 32±8mg/dl. After adjusting for demographics and vascular risk factors, there was an inverse association between HDL3-C and plaque area (per mg/dl: beta=-0.26 at the 75th percentile, p=0.001 and beta=-0.32 at the 90th percentile, p=0.02). A positive association was observed between HDL2-C and plaque thickness (per mg/dl; beta=0.02 at the 90% percentile, p=0.003). HDL-C was associated with plaque area (per mg/dl: beta=-0.18 at the 90th percentile, p=0.01), but only among Hispanics. Conclusion: In our cohort we observed an inverse association between HDL3-C and plaque area and a positive association between HDL2-C and plaque thickness. HDL-C subfractions may have different contributions to the risk of vascular disease. More studies are needed to fully elucidate HDL-C anti-atherosclerotic functions in order to improve HDL-based treatments in prevention of vascular disease and stroke.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
Issue number1
StatePublished - Nov 1 2014


  • Carotid plaque
  • High-density lipoprotein
  • High-density lipoprotein subfractions

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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