High-Density Lipoprotein and Glycosylated Hemoglobin in Nondiabetic Individuals

Jay M. Sosenko, Denise B. Kubrusly, Ronald B. Goldberg, Arthur M. Fournier, Sung L. Hsia, Maria T. Gadia, Jay S. Skyler

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

• We investigated associations of high-density-lipoprotein (HDL) cholesterol, apolipoprotein A-I, and triglyceride levels with hemoglobin A<inf>1</inf> (HbA<inf>1</inf>) and insulin levels in nondiabetic subjects (137 women and 111 men). In women, HDL cholesterol, apolipoprotein A-I, and log-triglyceride values were significantly correlated with those of HbA, and log-fasting insulin. These univariate associations persisted when age and Quetelet’s index were included as covariates in multiple regression analyses. Conversely, univariate associations of HDL cholesterol and log-triglyceride levels with Quetelet’s index were diminished by the addition of insulin values to multivariate models. Insulin levels and Quetelet’s index were highly correlated. Although there were weaker associations in men, apolipoprotein A-I and HbA, values were inversely related. These data suggest that HDL cholesterol and apolipoprotein A-I levels are closely linked to glucose metabolism in nondiabetic individuals.

Original languageEnglish (US)
Pages (from-to)1521-1524
Number of pages4
JournalArchives of Internal Medicine
Volume146
Issue number8
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Internal Medicine

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