High-Content Screening Applied to Nervous System Injury: Advantages, Challenges, and Proof of Principle

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Unbiased screening has resulted in major conceptual and technical breakthroughs in fields as diverse as cancer biology and retinal development. A relatively new approach to unbiased screening, high-content screening (HCS), allows the quantitative analysis of complex cellular phenotypes as an outcome measure to search for genes and compounds that produce a particular cellular profile. This chapter will describe the advantages of this approach when applied to neural regeneration and technical difficulties that need to be overcome. Several examples in which HCS has uncovered genes and compounds that can enhance neuroprotection and/or regeneration will be described.

Original languageEnglish (US)
Title of host publicationNeural Regeneration
PublisherElsevier Inc.
Pages411-419
Number of pages9
ISBN (Print)9780128018347, 9780128017326
DOIs
StatePublished - Feb 6 2015

Keywords

  • Axon degeneration
  • Axon regeneration
  • Drug discovery
  • High content screening
  • Neurite growth
  • Neuroprotection

ASJC Scopus subject areas

  • Medicine(all)

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