High Altitude Is an Independent Risk Factor for Developing a Pulmonary Embolism, but Not a Deep Vein Thrombosis Following a 1- to 2-Level Lumbar Fusion

Chester J. Donnally, Ajit M. Vakharia, Jonathan I. Sheu, Rushabh M. Vakharia, Dhanur Damodar, Kartik Shenoy, Joseph P. Gjolaj

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Study Design: Retrospective study. Objective: To identify if a 1- to 2-level posterior lumbar fusion at higher altitude is an independent risk factor for postoperative deep vein thrombosis (DVT) and pulmonary embolism (PE). Methods: A national Medicare database was queried for all patients undergoing 1- to 2-level lumbar fusions from 2005 to 2014. Those with a prior history of DVT, PE, coagulopathy, or peripheral vascular complications were excluded to better isolate altitude as the dependent variable. The groups were matched 1:1 based on age, gender, and comorbidities to limit potential cofounders. Using ZIP codes of the hospitals where the procedure occurred, we separated our patients into high (>4000 feet) and low (<100 feet) altitudes to investigate postoperative rates of DVTs and PEs at 90 days. Results: Compared with lumbar fusions performed at low-altitude centers, patients undergoing the same procedure at high altitude had significantly higher PE rates (P =.010) at 90 days postoperatively, and similar rates of 90-day postoperative DVTs (P =.078). There were no significant differences in age or comorbidities between these cohorts due to our strict matching process (P = 1.00). Conclusion: Spinal fusions performed at altitudes >4000 feet incurred higher PE rates in the first 90 days compared with patients receiving the same surgery at <100 feet but did not incur higher rates of postoperative DVTs.

Original languageEnglish (US)
Pages (from-to)729-734
Number of pages6
JournalGlobal Spine Journal
Volume9
Issue number7
DOIs
StatePublished - Oct 1 2019

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Pulmonary Embolism
Venous Thrombosis
Medicare
Blood Vessels
Comorbidity
Research Design
Retrospective Studies
Databases

Keywords

  • deep vein thrombosis
  • degenerative disc disease
  • high altitude
  • hypercoagulable state
  • low altitude
  • orthopedic surgery
  • peripheral vasculature
  • pulmonary embolism
  • spinal fusion
  • venous thromboembolism

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology

Cite this

High Altitude Is an Independent Risk Factor for Developing a Pulmonary Embolism, but Not a Deep Vein Thrombosis Following a 1- to 2-Level Lumbar Fusion. / Donnally, Chester J.; Vakharia, Ajit M.; Sheu, Jonathan I.; Vakharia, Rushabh M.; Damodar, Dhanur; Shenoy, Kartik; Gjolaj, Joseph P.

In: Global Spine Journal, Vol. 9, No. 7, 01.10.2019, p. 729-734.

Research output: Contribution to journalArticle

Donnally, Chester J. ; Vakharia, Ajit M. ; Sheu, Jonathan I. ; Vakharia, Rushabh M. ; Damodar, Dhanur ; Shenoy, Kartik ; Gjolaj, Joseph P. / High Altitude Is an Independent Risk Factor for Developing a Pulmonary Embolism, but Not a Deep Vein Thrombosis Following a 1- to 2-Level Lumbar Fusion. In: Global Spine Journal. 2019 ; Vol. 9, No. 7. pp. 729-734.
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abstract = "Study Design: Retrospective study. Objective: To identify if a 1- to 2-level posterior lumbar fusion at higher altitude is an independent risk factor for postoperative deep vein thrombosis (DVT) and pulmonary embolism (PE). Methods: A national Medicare database was queried for all patients undergoing 1- to 2-level lumbar fusions from 2005 to 2014. Those with a prior history of DVT, PE, coagulopathy, or peripheral vascular complications were excluded to better isolate altitude as the dependent variable. The groups were matched 1:1 based on age, gender, and comorbidities to limit potential cofounders. Using ZIP codes of the hospitals where the procedure occurred, we separated our patients into high (>4000 feet) and low (<100 feet) altitudes to investigate postoperative rates of DVTs and PEs at 90 days. Results: Compared with lumbar fusions performed at low-altitude centers, patients undergoing the same procedure at high altitude had significantly higher PE rates (P =.010) at 90 days postoperatively, and similar rates of 90-day postoperative DVTs (P =.078). There were no significant differences in age or comorbidities between these cohorts due to our strict matching process (P = 1.00). Conclusion: Spinal fusions performed at altitudes >4000 feet incurred higher PE rates in the first 90 days compared with patients receiving the same surgery at <100 feet but did not incur higher rates of postoperative DVTs.",
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