Abstract
We have analyzed heteroplasmy of mitochondrial DNA in clonal cultures from two patients with Kearns-Sayre syndrome, and have found that individual muscle or fibroblast clones contained either a mixed (i.e. heteroplasmic) population of normal and deleted mitochondrial DNAs, or only normal mitochondrial DNAs (i.e. homoplasmic at a level of detection of <1% deleted genomes). The heteroplasmic clones grew significantly more slowly than did "homoplasmic" clones, probably due to defects of respiratory chain enzymes containing mtDNA-encoded polypeptides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 765-771 |
| Number of pages | 7 |
| Journal | Biochemical and biophysical research communications |
| Volume | 160 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 28 1989 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Cite this
Moraes, C. T., Schon, E. A., DiMauro, S., & Miranda, A. F. (1989). Heteroplasmy of mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome. Biochemical and biophysical research communications, 160(2), 765-771. https://doi.org/10.1016/0006-291X(89)92499-6