Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival

C. A. Haney, Z. Sahenk, C. Li, Vance Lemmon, J. Roder, B. D. Trapp

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

This study investigated the function of the adhesion molecule L1 in unmyelinated fibers of the peripheral nervous system (PNS) by analysis of L1- deficient mice. We demonstrate that L1 is present on axons and Schwann cells of sensory unmyelinated fibers, but only on Schwann cells of sympathetic unmyelinated fibers. In L1-deficient sensory nerves, Schwann cells formed but failed to retain normal axonal ensheathment. L1-deficient mice had reduced sensory function and loss of unmyelinated axons, while sympathetic unmyelinated axons appeared normal. In nerve transplant studies, loss of axonal-L1, but no Schwann cell-L1, reproduced the L1-deficient phenotype. These data establish that heterophilic axonal-L1 interactions mediated adhesion between unmyelinated sensory axons and Schwann cells, stabilize the polarization of Schwann cell surface membranes, and mediate a trophic effect that assures axonal survival.

Original languageEnglish
Pages (from-to)1173-1183
Number of pages11
JournalJournal of Cell Biology
Volume146
Issue number5
DOIs
StatePublished - Sep 22 1999
Externally publishedYes

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Schwann Cells
Cell Adhesion
Axons
Adrenergic Fibers
Peripheral Nervous System
Systems Analysis
Cell Membrane
Transplants
Phenotype
Neurons

Keywords

  • Axonal degeneration
  • Cell adhesion
  • Cell polarity
  • L1
  • Myelin-associated glycoprotein

ASJC Scopus subject areas

  • Cell Biology

Cite this

Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. / Haney, C. A.; Sahenk, Z.; Li, C.; Lemmon, Vance; Roder, J.; Trapp, B. D.

In: Journal of Cell Biology, Vol. 146, No. 5, 22.09.1999, p. 1173-1183.

Research output: Contribution to journalArticle

Haney, C. A. ; Sahenk, Z. ; Li, C. ; Lemmon, Vance ; Roder, J. ; Trapp, B. D. / Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival. In: Journal of Cell Biology. 1999 ; Vol. 146, No. 5. pp. 1173-1183.
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