Heterogeneity of immune responsiveness in healthy elderly subjects

Wilma Barcellini, Maria Orietta Borghi, Chiara Sguotti, Roberto Palmieri, Daniela Frasca, Pier Luigi Meroni, Gino Doria, Carlo Zanussi

Research output: Contribution to journalArticle

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Abstract

We studied a group of healthy elderly subjects (satisfying the SENIEUR Protocol admission criteria), chosen as a model of age-associated immune deficiency on the basis of their reduced skin reactivity to recall antigens. Results show that aged subjects, taken as a whole, display impaired T-cell functions: reduced blastogenetic responses to mitogens, IL-2 production, responsiveness to exogenous IL-2, and percentage of Tac positive blasts. However, the age-associated immune defect shows a wide range of impairment, even in a relatively homogeneous group of anergic/hypoergic subjects. In fact, a considerable proportion of our elderly subjects displays responses comparable with those of adult controls. These observations suggest that (a) immune deficiency is not a characteristic of aging per se; (b) cutaneous delayed hypersensitivity is not a criterion sensitive enough to identify people with age-associated immune deficit; and (c) more than one test is required to evaluate T-cell impairment in aging.

Original languageEnglish
Pages (from-to)142-151
Number of pages10
JournalClinical Immunology and Immunopathology
Volume47
Issue number2
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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Interleukin-2
Healthy Volunteers
T-Lymphocytes
Skin
Delayed Hypersensitivity
Mitogens
Antigens

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

Barcellini, W., Borghi, M. O., Sguotti, C., Palmieri, R., Frasca, D., Meroni, P. L., ... Zanussi, C. (1988). Heterogeneity of immune responsiveness in healthy elderly subjects. Clinical Immunology and Immunopathology, 47(2), 142-151. https://doi.org/10.1016/0090-1229(88)90067-0

Heterogeneity of immune responsiveness in healthy elderly subjects. / Barcellini, Wilma; Borghi, Maria Orietta; Sguotti, Chiara; Palmieri, Roberto; Frasca, Daniela; Meroni, Pier Luigi; Doria, Gino; Zanussi, Carlo.

In: Clinical Immunology and Immunopathology, Vol. 47, No. 2, 01.01.1988, p. 142-151.

Research output: Contribution to journalArticle

Barcellini, W, Borghi, MO, Sguotti, C, Palmieri, R, Frasca, D, Meroni, PL, Doria, G & Zanussi, C 1988, 'Heterogeneity of immune responsiveness in healthy elderly subjects', Clinical Immunology and Immunopathology, vol. 47, no. 2, pp. 142-151. https://doi.org/10.1016/0090-1229(88)90067-0
Barcellini, Wilma ; Borghi, Maria Orietta ; Sguotti, Chiara ; Palmieri, Roberto ; Frasca, Daniela ; Meroni, Pier Luigi ; Doria, Gino ; Zanussi, Carlo. / Heterogeneity of immune responsiveness in healthy elderly subjects. In: Clinical Immunology and Immunopathology. 1988 ; Vol. 47, No. 2. pp. 142-151.
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