Heterogeneity of human colony-forming cells (CFUc) with respect to their sensitivity to chloramphenicol

A. M. Miller, M. A. Gross, Adel A Yunis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Human granulocyte-macrophage progenitor cells (CFUc) fractionated by velocity sedimentation at unit gravity exhibit heterogeneity with respect to inhibition by the drug chloramphenicol (CAP). An inverse correlation is observed between sedimentation velocity and sensitivity to CAP, e.g., increasing sensitivity with decreasing velocity. This heterogeneity is not a result of protection by endogenously produced colony stimulating factor since the same result obtains after removal of adherent cell populations. This heterogeneity in CFUc sensitivity to CAP may be a determining factor in the variability of bone marrow suppression by the drug.

Original languageEnglish (US)
Pages (from-to)236-242
Number of pages7
JournalExperimental Hematology
Volume8
Issue number3
StatePublished - 1980

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Chloramphenicol
Colony-Stimulating Factors
Granulocyte-Macrophage Progenitor Cells
Gravitation
Pharmaceutical Preparations
Bone Marrow
Population

ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Genetics
  • Hematology
  • Oncology
  • Transplantation

Cite this

Heterogeneity of human colony-forming cells (CFUc) with respect to their sensitivity to chloramphenicol. / Miller, A. M.; Gross, M. A.; Yunis, Adel A.

In: Experimental Hematology, Vol. 8, No. 3, 1980, p. 236-242.

Research output: Contribution to journalArticle

Miller, A. M. ; Gross, M. A. ; Yunis, Adel A. / Heterogeneity of human colony-forming cells (CFUc) with respect to their sensitivity to chloramphenicol. In: Experimental Hematology. 1980 ; Vol. 8, No. 3. pp. 236-242.
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