Abstract
Human granulocyte-macrophage progenitor cells (CFUc) fractionated by velocity sedimentation at unit gravity exhibit heterogeneity with respect to inhibition by the drug chloramphenicol (CAP). An inverse correlation is observed between sedimentation velocity and sensitivity to CAP, e.g., increasing sensitivity with decreasing velocity. This heterogeneity is not a result of protection by endogenously produced colony stimulating factor since the same result obtains after removal of adherent cell populations. This heterogeneity in CFUc sensitivity to CAP may be a determining factor in the variability of bone marrow suppression by the drug.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 236-242 |
| Number of pages | 7 |
| Journal | Experimental Hematology |
| Volume | 8 |
| Issue number | 3 |
| State | Published - 1980 |
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ASJC Scopus subject areas
- Cancer Research
- Cell Biology
- Genetics
- Hematology
- Oncology
- Transplantation
Cite this
Heterogeneity of human colony-forming cells (CFUc) with respect to their sensitivity to chloramphenicol. / Miller, A. M.; Gross, M. A.; Yunis, Adel A.
In: Experimental Hematology, Vol. 8, No. 3, 1980, p. 236-242.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Heterogeneity of human colony-forming cells (CFUc) with respect to their sensitivity to chloramphenicol
AU - Miller, A. M.
AU - Gross, M. A.
AU - Yunis, Adel A
PY - 1980
Y1 - 1980
N2 - Human granulocyte-macrophage progenitor cells (CFUc) fractionated by velocity sedimentation at unit gravity exhibit heterogeneity with respect to inhibition by the drug chloramphenicol (CAP). An inverse correlation is observed between sedimentation velocity and sensitivity to CAP, e.g., increasing sensitivity with decreasing velocity. This heterogeneity is not a result of protection by endogenously produced colony stimulating factor since the same result obtains after removal of adherent cell populations. This heterogeneity in CFUc sensitivity to CAP may be a determining factor in the variability of bone marrow suppression by the drug.
AB - Human granulocyte-macrophage progenitor cells (CFUc) fractionated by velocity sedimentation at unit gravity exhibit heterogeneity with respect to inhibition by the drug chloramphenicol (CAP). An inverse correlation is observed between sedimentation velocity and sensitivity to CAP, e.g., increasing sensitivity with decreasing velocity. This heterogeneity is not a result of protection by endogenously produced colony stimulating factor since the same result obtains after removal of adherent cell populations. This heterogeneity in CFUc sensitivity to CAP may be a determining factor in the variability of bone marrow suppression by the drug.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018900501&partnerID=8YFLogxK
M3 - Article
C2 - 6970133
AN - SCOPUS:0018900501
VL - 8
SP - 236
EP - 242
JO - Experimental Hematology
JF - Experimental Hematology
SN - 0301-472X
IS - 3
ER -