Herpesvirus tamarinus and its relation to herpes simplex virus

Research output: Contribution to journalArticle

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Abstract

We have characterized Herpesvirus tamarinus (HT), a virus of New World primates related to herpes simplex virus. HT virion DNA cross-hybridized appreciably with herpes simplex virus type 1 (HSV-1) DNA. The HT-HSV-1 cross-hybridizing DNA sequences were distributed over the length of the genome; some DNA sequences, however, were apparently more homologous than others. HT virion DNA was estimated from the sum of restriction endonuclease fragments to have a mol. wt. of 98 X 106. Only 1 molar fragments were found with some restriction endonucleases and 0.5 and 1 molar fragments were found with other restriction endonucleases but no evidence was found for 0.25 molar fragments. Independent isolates of HT from different species of South American primates gave nearly identical restriction endonuclease cleavage patterns of virion DNA. Although cross-reacting antigenic proteins of HT and HSV-1 were not detected by neutralization or immunofluorescence tests, cross-reacting antigenic proteins were detected by SDS-polyacrylamide gel electrophoresis of immunoprecipitates of 35S-labelled infected cell extracts.

Original languageEnglish (US)
Pages (from-to)119-130
Number of pages12
JournalJournal of General Virology
Volume56
Issue number1
StatePublished - 1981
Externally publishedYes

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Herpesviridae
Simplexvirus
DNA Restriction Enzymes
Human Herpesvirus 1
Virion
DNA
Primates
Cell Extracts
Fluorescent Antibody Technique
Polyacrylamide Gel Electrophoresis
Proteins
Genome
Viruses

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Herpesvirus tamarinus and its relation to herpes simplex virus. / Desrosiers, Ronald Charles; Falk, L. A.

In: Journal of General Virology, Vol. 56, No. 1, 1981, p. 119-130.

Research output: Contribution to journalArticle

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