Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro

M. Kiyotaki, Ronald Charles Desrosiers, N. L. Letvin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Herpesvirus saimiri induces a fatal lymphoproliferative syndrome in a variety of New World primate species. We now show that cell lines derived from PBL of the common marmoset by in vitro-immortalization with H. saimiri strain 11 represent a remarkably restricted lymphocyte population. These cell lines have NK cell function, phenotypically express both suppressor/cytotoxic (T8) and NK cell (NKH1)-associated antigens, and express a T cell receptor. This subpopulation of lymphocytes is a very minor population of cells in the peripheral blood of common marmosets (≤3%). The specificity in the interaction between H. saimiri strain 11 and a subpopulation of common marmoset lymphocytes represents an example of a restricted viral lymphotropism and may have important implications for the disease induced by this virus in New World monkeys.

Original languageEnglish (US)
Pages (from-to)926-931
Number of pages6
JournalJournal of Experimental Medicine
Volume164
Issue number3
StatePublished - 1986
Externally publishedYes

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Saimiriine Herpesvirus 2
CD8-Positive T-Lymphocytes
Callithrix
Lymphocyte Subsets
Natural Killer Cells
Platyrrhini
Lymphocytes
Cell Line
Virus Diseases
T-Cell Antigen Receptor
Primates
Population
Antigens
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology

Cite this

Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro. / Kiyotaki, M.; Desrosiers, Ronald Charles; Letvin, N. L.

In: Journal of Experimental Medicine, Vol. 164, No. 3, 1986, p. 926-931.

Research output: Contribution to journalArticle

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