Abstract
Herpesvirus saimiri induces a fatal lymphoproliferative syndrome in a variety of New World primate species. We now show that cell lines derived from PBL of the common marmoset by in vitro-immortalization with H. saimiri strain 11 represent a remarkably restricted lymphocyte population. These cell lines have NK cell function, phenotypically express both suppressor/cytotoxic (T8) and NK cell (NKH1)-associated antigens, and express a T cell receptor. This subpopulation of lymphocytes is a very minor population of cells in the peripheral blood of common marmosets (≤3%). The specificity in the interaction between H. saimiri strain 11 and a subpopulation of common marmoset lymphocytes represents an example of a restricted viral lymphotropism and may have important implications for the disease induced by this virus in New World monkeys.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 926-931 |
| Number of pages | 6 |
| Journal | Journal of Experimental Medicine |
| Volume | 164 |
| Issue number | 3 |
| State | Published - 1986 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro. / Kiyotaki, M.; Desrosiers, Ronald Charles; Letvin, N. L.
In: Journal of Experimental Medicine, Vol. 164, No. 3, 1986, p. 926-931.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Herpesvirus saimiri strain 11 immortalizes a restricted marmoset T8 lymphocyte subpopulation in vitro
AU - Kiyotaki, M.
AU - Desrosiers, Ronald Charles
AU - Letvin, N. L.
PY - 1986
Y1 - 1986
N2 - Herpesvirus saimiri induces a fatal lymphoproliferative syndrome in a variety of New World primate species. We now show that cell lines derived from PBL of the common marmoset by in vitro-immortalization with H. saimiri strain 11 represent a remarkably restricted lymphocyte population. These cell lines have NK cell function, phenotypically express both suppressor/cytotoxic (T8) and NK cell (NKH1)-associated antigens, and express a T cell receptor. This subpopulation of lymphocytes is a very minor population of cells in the peripheral blood of common marmosets (≤3%). The specificity in the interaction between H. saimiri strain 11 and a subpopulation of common marmoset lymphocytes represents an example of a restricted viral lymphotropism and may have important implications for the disease induced by this virus in New World monkeys.
AB - Herpesvirus saimiri induces a fatal lymphoproliferative syndrome in a variety of New World primate species. We now show that cell lines derived from PBL of the common marmoset by in vitro-immortalization with H. saimiri strain 11 represent a remarkably restricted lymphocyte population. These cell lines have NK cell function, phenotypically express both suppressor/cytotoxic (T8) and NK cell (NKH1)-associated antigens, and express a T cell receptor. This subpopulation of lymphocytes is a very minor population of cells in the peripheral blood of common marmosets (≤3%). The specificity in the interaction between H. saimiri strain 11 and a subpopulation of common marmoset lymphocytes represents an example of a restricted viral lymphotropism and may have important implications for the disease induced by this virus in New World monkeys.
UR - http://www.scopus.com/inward/record.url?scp=0022474859&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022474859&partnerID=8YFLogxK
M3 - Article
C2 - 3018122
AN - SCOPUS:0022474859
VL - 164
SP - 926
EP - 931
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
SN - 0022-1007
IS - 3
ER -