Herpesvirus saimiri oncogene STP-C488 encodes a phosphoprotein

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The STP-C488 open reading frame of herpesvirus saimiri encodes an oncoprotein that has transforming and tumor-inducing activities independent of the rest of the herpesvirus genome. STP-C488 protein has an unusual, membrane-associated, fibrous structure and is located primarily in perinuclear compartments. We now report that STP-C488 is phosphorylated in vivo. The phosphorylated form, which accounted for about 15% of STP-C488 in transformed cells, migrated slightly more slowly through sodium dodecyl sulfate-polyacrylamide gels than unphosphorylated STP-C488. A serine residue near the amino terminus was shown to be the site of phosphorylation. However, phosphorylation was not required for transformation of Rat-1 cells by STP-C488.

Original languageEnglish (US)
Pages (from-to)1777-1780
Number of pages4
JournalJournal of Virology
Volume66
Issue number3
StatePublished - 1992
Externally publishedYes

Fingerprint

Saimiriine herpesvirus 2
Saimiriine Herpesvirus 2
phosphoproteins
oncogenes
Phosphoproteins
Oncogenes
phosphorylation
Phosphorylation
Herpesviridae
Oncogene Proteins
sodium dodecyl sulfate
polyacrylamide
Sodium Dodecyl Sulfate
serine
Serine
Open Reading Frames
open reading frames
gels
Genome
cells

ASJC Scopus subject areas

  • Immunology

Cite this

Herpesvirus saimiri oncogene STP-C488 encodes a phosphoprotein. / Jung, J. U.; Desrosiers, Ronald Charles.

In: Journal of Virology, Vol. 66, No. 3, 1992, p. 1777-1780.

Research output: Contribution to journalArticle

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