Herpes simplex virus type 2 seropositivity in a sexually transmitted disease clinic in Israel

Paul A. Feldman, Jordan Steinberg, Ralph Madeb, Guy Bar, Ofer Nativ, Joseph Tal, Isaac Srugo

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Seroepidemeliogic surveys have provided valuable information on the prevalence and incidence of herpes simplex virus-2 infection in general and in selected populations. Objective: To review the reliability of traditional diagnostic approaches in herpes simplex virus-2 infection. Methods: In this cross-sectional study, 472 patients attending a clinic for sexually transmitted disease in 1998-1999 were evaluated for HSV-2 infection through collection of epidemiologic and clinical data. HSV-2 infection was confirmed by the presence of specific viral glycoprotein, gG-2, antibody in sera. Results: The seroprevalence of HSV-2 among clinic attendees was 9.33%. Of these attendees only 22% presented with or reported a history of typical vesicular lesions in the genital area. Infection rate was higher in patients with multiple sex partners (20.8% vs. 8.7%, P ≤ 0.0023), in individuals aged 30 or older (12.6 vs. 6.4%, P = 0.03) and in the Israeli Jewish population as compared to the Israeli Arab population (11.1% vs. 2.4%, P ≤ 0.01). Females with multiple sex partners exhibited higher rates of infection than did their male counterparts (50 vs. 16.1%, P ≤ 0.0275). Conclusion: The findings support the need for HSV-2 serologic testing in patients presenting to STD clinics even when typical genital lesions are not evident but where risk factors for HSV-2 infection are identified.

Original languageEnglish (US)
Pages (from-to)626-628
Number of pages3
JournalIsrael Medical Association Journal
Issue number9
StatePublished - Sep 1 2003
Externally publishedYes


  • Antibody
  • Glycoprotein
  • Herpes simplex virus
  • Infection
  • Sexually transmitted disease

ASJC Scopus subject areas

  • Medicine(all)
  • Bioengineering


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