TY - JOUR
T1 - Herpes Simplex Virus endotheliitis following descemet's membrane endothelial keratoplasty
AU - Zarei-Ghanavati, Siamak
AU - Alizadeh, Reza
AU - Yoo, Sonia H.
N1 - Publisher Copyright:
© 2015 Journal of Ophthalmic and Vision Research.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Purpose: To report a case of herpes simplex virus (HSV) endotheliitis following simultaneous phacoemulsification, intraocular lens (IOL) implantation and descemet's membrane endothelial keratoplasty (DMEK). Case Report: A;45 year-old female with corneal endothelial decompensation and a mature cataract, and history of anterior uveitis underwent simultaneous phacoemulsification, IOL implantation and DMEK. Increased corneal edema and descemet's membrane (DM) detachment occurred on postoperative day 3 and 5, respectively. One week after surgery, active keratic precipitates (KPs) appeared. Polymerase chain reaction (PCR) analysis was performed on an aqueous sample which was positive for herpes simplex virus (HSV). After initiating oral acyclovir and frequent topical corticosteroids, the corneal edema resolved and the donor tissue became spontaneously reattached to the recipient corneal stroma. Conclusion:HSV endotheliitis may occur in the early postoperative period after DMEK and manifest as endothelial dysfunction leading to donor detachment. Anti-viral medication may help treat the acute phase and reduce the risk of recurrence.
AB - Purpose: To report a case of herpes simplex virus (HSV) endotheliitis following simultaneous phacoemulsification, intraocular lens (IOL) implantation and descemet's membrane endothelial keratoplasty (DMEK). Case Report: A;45 year-old female with corneal endothelial decompensation and a mature cataract, and history of anterior uveitis underwent simultaneous phacoemulsification, IOL implantation and DMEK. Increased corneal edema and descemet's membrane (DM) detachment occurred on postoperative day 3 and 5, respectively. One week after surgery, active keratic precipitates (KPs) appeared. Polymerase chain reaction (PCR) analysis was performed on an aqueous sample which was positive for herpes simplex virus (HSV). After initiating oral acyclovir and frequent topical corticosteroids, the corneal edema resolved and the donor tissue became spontaneously reattached to the recipient corneal stroma. Conclusion:HSV endotheliitis may occur in the early postoperative period after DMEK and manifest as endothelial dysfunction leading to donor detachment. Anti-viral medication may help treat the acute phase and reduce the risk of recurrence.
KW - Descemet's Membrane Endothelial Keratoplasty
KW - Endotheliitis
KW - Herpes Simplex Virus
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U2 - 10.4103/2008-322X.163764
DO - 10.4103/2008-322X.163764
M3 - Article
AN - SCOPUS:84940782039
VL - 10
SP - 184
EP - 186
JO - Journal of Ophthalmic and Vision Research
JF - Journal of Ophthalmic and Vision Research
SN - 2008-2010
IS - 2
ER -